目前已证实肌肉是具有多向分化潜能的成体干细胞的一个储存库。研究者认为骨骼肌中至少有两种干细胞:肌卫星细胞(muscle satellite cells)和肌源干细胞(muscle-derived stem cells, MDSCs),并且使用几种方法从肌肉中分离获得不同类群的MDSCs。研究发现分离这些细胞的方法影响干细胞的特征。本文对MDSCs的行为、生物学特征、分离、分化及其在治疗组织器官修复和再生中应用的可能性等作一概括介绍。
Muscle recently has been identified as a good source of adult stem cells that can differentiate into cells of different lineages. Researchers have identified two types of stem cells in skeletal muscle. Further research is necessary to delineate the relationship between different populations of muscle-derived stem cells(MDSCs)and between MDSCs and other adult stem cells. The methods used to isolate these cells appear to influence the stem cell characteristics. As these efforts continue, the potential for MDSCs-based therapy for other musculoskeletal injuries, as well as for cardiac and smooth muscle injuries, is currently being explored. This article summarizes the behavior, biocharacteristic, isolation, differentiation and the probability of application to regenerate lost or diseased tissue of MDSCs.
李俊玲,王世立,韩金祥. 肌源干细胞研究进展[J]. 中国生物工程杂志, 2007, 27(5): 125-130.
. Recent progress in research on muscle-derived stem cells. China Biotechnology, 2007, 27(5): 125-130.
https://manu60.magtech.com.cn/biotech/CN/ 或 https://manu60.magtech.com.cn/biotech/CN/Y2007/V27/I5/125
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