人类8型疱疹病毒（human herpesvirus-8，HHV-8）又称卡波氏肉瘤相关疱疹病毒（Kapo- si's sarcoma- associated herpesvirus，KSHV），是一种新的肿瘤病毒，目前被认为是卡波氏肉瘤（Kaposi's sarcoma，KS）致病因子,并且与primary effusion lymphoma （PEL）和multicentric Castleman's disease（MCD）相关。该病毒编码许多蛋白,包括潜伏感染相关蛋白，裂解感染相关蛋白和HHV-8特有基因表达蛋白，在KS和HHV-8相关疾病的发病中起到关键作用。

Human herpesvirus-8 (HHV-8) also referred to as Kaposi's sarcoma-associated herpesvi- rus (KSHV)，is a novel tumor causing virus，which is thought to be the etiologic agent of KS ,and also is associated with primary effusion lymphoma （PEL) and multicentric castleman's disease （MCD）.HHV-8 encodes a number of viral proteins, including the proteins associated with HHV-8 latent infection and lyt- ic infection，and the proteins unique to HHV-8，which are critical players in the development of KS and HHV-8-associated diseases.