在许多国家糖尿病都是发病率和死亡率最高的疾病。是由胰腺胰岛素分泌细胞受损引起的胰岛素绝对分泌不足或对胰岛素敏感性下降而引起的相对不足,以慢性高血糖为特征。胰岛移植已被证实可使血糖正常,但存在供体来源不足和移植免疫排斥问题,限制了其应用。骨髓间充质干细胞具有分化为胰岛细胞的潜能，可能成为胰岛移植治疗糖尿病的新来源。
Diabetes mellitus is one of the heading causes of morbidity and mortality in many countries .It caused by an absolute insulin deficiency due to the destruction of insulin secreting pancreatic cells or by a relative insulin deficiency due to decreased insulin sensitivity, characterized with choronic hyperglycemia. Islet transplantation has been shown to restore normoglycemia ,but a limited supply and graft immune rejection prevents this therapy. Mesenchymal stem cells have the potency of differentiation into islet cells, it may act as a new source of islet transplantation in diabetes mellitus treatment.
裴学莲,慕晓玲. 骨髓间充质干细胞分化为分泌胰岛素样细胞研究进展[J]. 中国生物工程杂志, 2006, 26(0): 230-233.
. Inducing of insulin producing like cell with bone marrow-derived mesenchymal stem cell. China Biotechnology, 2006, 26(0): 230-233.
https://manu60.magtech.com.cn/biotech/CN/ 或 https://manu60.magtech.com.cn/biotech/CN/Y2006/V26/I0/230
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