乳酸杆菌（Lactobacillus）作为一种益生菌是大自然赋予人类的宝贵财富,它作为益生菌已有相当长的历史。是一类广泛用于食品工业的革兰阳性杆菌,利用分子生物学技术可改造乳酸杆菌的性状，满足人类需要。但相对于大肠杆菌，乳酸杆菌基因工程尚处于开发阶段。最近,国内外学者开始把乳酸杆菌作为外源基因表达载体有目的、有选择地研制新一代微生态制剂。近20年中，研究者构建了多种乳酸杆菌载体，并表达了多种蛋白。鉴于乳酸杆菌是人体的正常菌群，因此把乳酸杆菌作为载体来表达蛋白,将会是一个很具有诱惑力的研究方向。
Lactobacillus, a natural treasure, has been used as a kind of probiotics for a long time. Molecular techniques are being employed to modify this Gram-positive bacterium as to better serve food industry, but compare with E.coil, this work is just initial. Recently, Lactobacillus has been developed as a vector for exogenous gene expression to prepare new probiotics. Recent 20 years, Lactobacillus vectors have been constructed and successfully induced to express proteins. As an important component in normal microbial flora in human body, Lactobacillus vectors are very promising. Here, new advances in this aspect are provided.
郄翠仙,柴俊,张以芳,聂福平. 乳酸杆菌作为受体菌的研究及应用[J]. 中国生物工程杂志, 2006, 26(0): 212-215.
. The study and application of Lactobacillus as vector. China Biotechnology, 2006, 26(0): 212-215.
https://manu60.magtech.com.cn/biotech/CN/ 或 https://manu60.magtech.com.cn/biotech/CN/Y2006/V26/I0/212
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