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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2023, Vol. 43 Issue (4): 71-78    DOI: 10.13523/j.cb.2210035
综述     
氧化石墨烯在骨组织工程中的应用*
纪玉洁,秦汉,向学熔()
重庆医科大学口腔医学院 口腔疾病与生物医学重庆市重点实验室 重庆市高校市级口腔生物医学工程重点实验室 重庆 401147
Application of Graphene Oxide in Bone Tissue Engineering
JI Yu-jie,QIN Han,XIANG Xue-rong()
Stomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 401147, China
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摘要：

传统骨组织工程支架材料存在强度不足、生物活性低等缺点。近年来,碳纳米材料在骨再生方面展现出独特的优势。氧化石墨烯(graphene oxide,GO)是一种具有代表性的二维碳纳米材料,作为石墨烯的氧化形式,GO具有优异的力学性能、良好的生物相容性、大比表面积、易于改性等特点。GO不仅能够直接促进干细胞黏附、增殖和分化,还可以改善传统支架的机械性能、生物活性、抗菌能力、免疫调节能力等,基于GO的复合材料有望成为理想的骨再生支架。综述GO的物理化学性能、生物相容性、生物降解和清除等特性,总结GO作为涂层、控释材料和复合支架在骨组织工程中的最新应用,并对其未来研究方向进行展望。
关键词： 氧化石墨烯;  纳米材料;  骨组织工程;  骨再生;  生物医学    
Abstract:

Traditional bone tissue engineering scaffold materials have disadvantages, such as insufficient strength and low bioactivity. In recent years, nanomaterials have shown many unique advantages in bone regeneration. Graphene oxide (GO), an oxidized form of graphene, is a representative two-dimensional nanomaterial. Many studies have shown that GO has excellent mechanical properties, good biocompatibility, large specific surface area and easy modification.GO can not only directly promote the adhesion, proliferation and differentiation of stem cells, but also improve the mechanical properties, biological activity, antibacterial ability and immunomodulatory ability of traditional scaffolds. GO-based composite materials are expected to become ideal scaffolds for bone regeneration. This paper first describes the physicochemical properties, biocompatibility, biodegradation and clearance of GO. Then,the latest applications of GO as coatings, controlled release agents and composite scaffolds in bone tissue engineering were summarized. At last, the advantages and challenges of GO are analyzed, and the future research direction is forecasted.
Key words: Graphene oxide    Nanomaterials    Bone tissue engineering    Bone regeneration    Biomedicine
收稿日期: 2022-10-24 出版日期: 2023-05-04
ZTFLH:  TB32Q819  
基金资助: 国家自然科学基金(82001063);重庆市自然科学基金博士后科学基金(cstc2020jcyj-bshX0108)
通讯作者: **电子信箱:cqzxfxp@sina.com   
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纪玉洁
秦汉
向学熔

引用本文:

纪玉洁, 秦汉, 向学熔. 氧化石墨烯在骨组织工程中的应用*[J]. 中国生物工程杂志, 2023, 43(4): 71-78.

JI Yu-jie, QIN Han, XIANG Xue-rong. Application of Graphene Oxide in Bone Tissue Engineering. China Biotechnology, 2023, 43(4): 71-78.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2210035    或    https://manu60.magtech.com.cn/biotech/CN/Y2023/V43/I4/71

图1  氧化石墨烯的结构及在骨组织工程中的应用
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