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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2023, Vol. 43 Issue (4): 59-70    DOI: 10.13523/j.cb.2209064
综述     
Wnt/β-catenin信号通路与肝癌
杨涛铧1,陈观源1,陈序1,李强1,张清1,吴跃锐2,蒋建伟3,李震东1,*()
1.暨南大学附属第一医院 广州 510630
2.暨南大学附属顺德医院 佛山 528306
3.暨南大学基础医学与公共卫生学院 广州 510632
Wnt/β-catenin Signal Pathway and Hepatocellular Carcinoma
YANG Tao-hua1,CHEN Guan-yuan1,CHEN Xu1,LI Qiang1,ZHANG Qing1,WU Yue-rui2,JIANG Jian-wei3,LI Zhen-dong1,*()
1. The First Affiliated Hospital of Jinan University, Guangzhou 510630, China
2. Shunde Hospital Affiliated to Jinan University, Foshan 528306, China
3. School of Medicine, Jinan University, Guangzhou 510632, China
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摘要：

肝细胞癌是常见的恶性肿瘤,其发病机制尚未完全明确。Wnt信号通路与人体内多种病理生理过程相关,其中肝癌的发生、发展可能与经典的Wnt/β-catenin信号通路密切相关。Wnt/β-catein信号通路通过表达癌症相关基因、激活肝星状细胞、调控肝干细胞行为、促进肝癌细胞侵袭转移等方式调控肝癌的发生、发展。Wnt/β-catein信号通路在肝癌发生、发展中的作用有望为肝癌研究提供新的思路。
关键词： 肝细胞癌;  信号通路;  Wnt;  β-catenin    
Abstract:

As a common human malignant tumor, the pathogenesis of hepatocellular carcinoma (HCC) has not been completely clarified. Wnt signaling pathway is related to a variety of pathophysiological processes in human body, among which the carcinogenesis and the development of HCC may be closely related to the classic Wnt/β-catenin signaling pathway. Wnt/β-catenin regulates HCC by expressing cancer-related genes, activating hepatic stellate cells, regulating liver stem cell behavior, and promoting the invasion and metastasis of cancer cells. The role of Wnt/β-catein signaling pathway in HCC is discussed.
Key words: Hepatocellular carcinoma (HCC)    Signal pathway    Wnt    β-Catenin
收稿日期: 2022-09-23 出版日期: 2023-05-04
ZTFLH:  R73Q257  
通讯作者: *电子信箱:victor7922@163.com   
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杨涛铧
陈观源
陈序
李强
张清
吴跃锐
蒋建伟
李震东

引用本文:

杨涛铧, 陈观源, 陈序, 李强, 张清, 吴跃锐, 蒋建伟, 李震东. Wnt/β-catenin信号通路与肝癌[J]. 中国生物工程杂志, 2023, 43(4): 59-70.

YANG Tao-hua, CHEN Guan-yuan, CHEN Xu, LI Qiang, ZHANG Qing, WU Yue-rui, JIANG Jian-wei, LI Zhen-dong. Wnt/β-catenin Signal Pathway and Hepatocellular Carcinoma. China Biotechnology, 2023, 43(4): 59-70.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2209064    或    https://manu60.magtech.com.cn/biotech/CN/Y2023/V43/I4/59

图1  Wnt/β-catenin通路的开放与关闭
图2  Wnt/β-catenin与hippo通路的关系
图3  Wnt/β-catenin与notch通路的关系
图4  Wnt/β-catenin与hedgehog通路的关系
图5  Wnt/β-catenin与其他通路的关系
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