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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2019, Vol. 39 Issue (6): 62-72    DOI: 10.13523/j.cb.20190609
研究报告     
高分子囊泡在药物释放体系的应用 *
曹文杰1,熊向源1,2,**(),龚妍春2,李资玲2,李玉萍2
1 江西科技师范大学药学院 南昌 330013
2 江西科技师范大学生命科学学院 南昌 330013
The Application of Polymersomes in Drug Delivery System
Wen-jie CAO1,Xiang-yuan XIONG1,2,**(),Yan-chun GONG2,Zi-ling LI2,Yu-ping LI2
1 School of Pharmacy, Jiangxi Normal University of Science and Technology, Nanchang 330013,China
2 School of Life Sciences,Jiangxi Normal University of Science and Technology,Nanchang 330013,China
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摘要：

高分子囊泡作为一种新型的纳米药物载体,具有生物可降解性、稳定性、生物相容性及可修饰的多功能化等特点。改变聚合物种类和亲水-疏水嵌段的比例,可以制备具有不同形态和膜特性的高分子囊泡。经过修饰后的高分子囊泡,可赋予其更多的功能,从而实现药物的控释和药物靶向的能力。对高分子囊泡的结构、组成和制备方法以及在药物释放体系的应用等方面进行了较为详细的综述,目的是了解高分子囊泡最新研究进展以及未来科学家们亟须解决的重要问题。
关键词： 高分子囊泡;  药物释放体系;  两亲性嵌段共聚物;  控释;  靶向    
Abstract:

As a novel kind of nano-drug carrier, the polymersomes have the characteristics of biodegradability, stability, biocompatibility and modifiable multi-functionalization and so on. Polymersomes can be prepared by changing polymer type and the ratio of hydrophilic - hydrophobic block, which possess different morphological and membrane properties. After modifiing polymersomes, more functions can be given to realize the ability of controlling drug release and targeting drugs. The structure, composition, preparation methods and the application of drug delivery system about polymersomes have been reviewed in detail. The purpose is to know the latest research progress of polymersomes and some important problems in this field need to be solved by scientists in the future.
Key words: Polymersomes    Drug delivery system    Amphiphilic block copolymer    Controlled release    Target
收稿日期: 2018-11-13 出版日期: 2019-07-12
ZTFLH:  Q819  
基金资助: * 国家自然科学基金(21664007);江西省主要学科学术和技术带头人培养计划(20153BCB22009);江西省高等学校科技落地计划资助项目(KJLD13071)
通讯作者: 熊向源     E-mail: xyxiong@gmail.com
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曹文杰
熊向源
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李资玲
李玉萍

引用本文:

曹文杰,熊向源,龚妍春,李资玲,李玉萍. 高分子囊泡在药物释放体系的应用 *[J]. 中国生物工程杂志, 2019, 39(6): 62-72.

Wen-jie CAO,Xiang-yuan XIONG,Yan-chun GONG,Zi-ling LI,Yu-ping LI. The Application of Polymersomes in Drug Delivery System. China Biotechnology, 2019, 39(6): 62-72.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20190609    或    https://manu60.magtech.com.cn/biotech/CN/Y2019/V39/I6/62

图1  脂质体(左)与高分子囊泡(右)的示意图[24]
图2  高分子囊泡的三维横截面示意图 [5]
图3  五嵌段共聚物分子式和微观结构及其透射电镜图[45]
图4  pH触发高分子囊泡的转化[47]
图5  癌细胞组织中纳米载体的形态转换和温度响应[65]
图6  包埋有亲水或疏水药物表面功能化的靶向高分子囊泡[4]
Block numbers Polymersomes Function Loaded-cargoes Formation
Diblock mPEG-PLGA Normal Dox; Tax Nanoemulsion[63]
FA-PEG-PCL Targeted DOX; PTX Thin-film hydration[34]
PTMA-PGA Smart DOX; γ-Fe2O3 Nanoprecipitation[48]
PDP-TEG Smart DOX; CRT Nanoprecipitation[65]
PDMAEM-mPEG Normal pDNA Nanoprecipitation[36]
PS-β-CD/PEO-Fc Smart Rhodamine B Not reported[66]
PEG45-b-P(Asp-co-AspGA);
PEG114-b-P(Asp-co-AspPBA)		 Smart Vancomycin Nanoprecipitation[67]
Triblock PLA-PEG-PLA Normal Atorvastatin; Lisinopril Nanoemulsion[40]
PAE-g-PCL-PEG Smart DOX·HCl Nanoprecipitation[47]
Block numbers Polymersomes Function Loaded-cargoes Formation
PBAE-PEG-PLA Smart Nile red Nanoprecipitation[69]
PEG-PAA(SH)-PDEA Normal BSA; Cc Nanoprecipitation[64]
PEO-b-P(DEA-stat-TMA) Smart DOX·HCl Nanoprecipitation[68]
Acupa-PEG-PTMBPEC-PSAC Targeted granzyme B Nanoprecipitation[38]
Poly[(HEMA-DTDPA)-mPEG Smart Cal Thin-film hydration[35]
Pentablock PLA-PEO-PPO-PEO-PLA Normal Insulin Nanoprecipitation[45]
表1  高分子囊泡在药物释放体系中的应用
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