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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2019, Vol. 39 Issue (4): 94-100    DOI: 10.13523/j.cb.20190412
综述     
诱导多能干细胞向雄性生殖细胞分化诱导物的研究进展 *
李欣1,赵中利1,罗晓彤2,曹阳1,张立春1,于永生1**(),金海国1**()
1 吉林省农业科学院畜牧科学分院 公主岭 136100
2 延边大学农学院 延吉 133002
Research Progress of in the Inducers Stimulating in Differentiation of iPS Cells into Male Germ Cells
Xin LI1,Zhong-li ZHAO1,Xiao-tong LUO2,Yang CAO1,Li-chun ZHANG1,Yong-sheng YU1**(),Hai-guo JIN1**()
1 Branch of Animal Husbandry, Jilin Academy of Agricultural Sciences, Gongzhuling 136100,China
2 Agricultural College, Yan Bian University, Yanji 133002, China
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摘要：

诱导多能干细胞(induced pluripotent stem cells,iPSCs)是利用细胞重编程技术人工获得的与胚胎干细胞(embryonic stem cells,ESCs)功能类似的细胞,能分化成包括三胚层在内的所有细胞类型,并且规避了ESCs的伦理学争议和移植后的免疫排斥问题,具有十分广阔的应用前景。对iPSCs体外诱导为生殖细胞所用的诱导物及其诱导效果进行了综述,生殖细胞发育机制的研究有望促进未来生殖和发育技术的进步。
关键词： 诱导多能干细胞;  雄性生殖细胞;  分化;  诱导物    
Abstract:

Induced pluripotent stem cells(iPSCs) refer to stem cells that are artificially produced by cellular reprogramming, which have similar functions to embryonic stem cells. They can differentiate into all cell types, and avoid the ethical controversy of ESCs and immune rejection after transplantation. They have a broad application prospect.The advances in the in vitro differentiation of male germ cells using iPSCs by different inducers was reviewed, the effect was also investigated. Exploring development mechanisms of germ cells is promising to promote future reproductive and developmental engineering technologies.
Key words: iPSCs    Male germ cells    Differentiation    Inducers
收稿日期: 2018-09-27 出版日期: 2019-05-08
ZTFLH:  Q813.5  
基金资助: * 吉林省农业科学院院创新工程资助项目(CXGC2018DC001)
通讯作者: 于永生,金海国     E-mail: yuyongsheng2002@163.com;khk1962@126.com
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李欣
赵中利
罗晓彤
曹阳
张立春
于永生
金海国

引用本文:

李欣,赵中利,罗晓彤,曹阳,张立春,于永生,金海国. 诱导多能干细胞向雄性生殖细胞分化诱导物的研究进展 *[J]. 中国生物工程杂志, 2019, 39(4): 94-100.

Xin LI,Zhong-li ZHAO,Xiao-tong LUO,Yang CAO,Li-chun ZHANG,Yong-sheng YU,Hai-guo JIN. Research Progress of in the Inducers Stimulating in Differentiation of iPS Cells into Male Germ Cells. China Biotechnology, 2019, 39(4): 94-100.

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https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20190412    或    https://manu60.magtech.com.cn/biotech/CN/Y2019/V39/I4/94

图1  iPS向雄性生殖细胞分化示意图
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