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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2018, Vol. 38 Issue (12): 76-81    DOI: 10.13523/j.cb.20181210
综述     
形状记忆聚合物在组织工程中的应用 *
郗来顺1,云鹏1,王元斗2,张冠宏3,邢泉生4,陈阳生5,宿烽1,2,**()
1 青岛科技大学化工学院 青岛 266042
2 青岛科技大学高性能聚合物研究院 青岛 266042
3 胜利油田中心医院 东营 257000
4 青岛市妇女儿童医院 青岛 266034
5 青岛正大海尔制药有限公司 青岛 266103
Application of Shape Memory Polymer in Tissue Engineering
XI Lai-shun1,YUN Peng1,WANG Yuan-dou2,ZHANG Guan-hong3,XING Quan-sheng4,CHEN Yang-sheng5,SU Feng1,2,**()
1 College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China
2 Institute of High Performance Polymers, Qingdao University of Science and Technology, Qingdao 266042, China
3 Shengli Oilfield Central Hospital, Dongying 257000, China
4 Qingdao Women and Children’s Hospital, Qingdao 266034, China;
5 Qingdao Chiatai Haier Pharmaceutical Co., LTD, Qingdao 266103, China
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摘要：

形状记忆聚合物是由固定相和可逆相构成的具有在外界刺激条件下诱导形状改变特性的一类高分子智能材料。相较于传统的形状记忆合金与陶瓷,其具有特定的生物可降解性、更高的机械性能调控空间、更强的形变恢复能力及更优良的生物相容性。凭借材料特性,近阶段针对形状记忆聚合物在组织工程领域的应用研究愈发广泛,包括血管组织、骨骼肌组织、神经组织与骨组织等方面。综述近年来形状记忆聚合物在多种组织工程领域研究中的实验创新、技术突破与应用拓展,例如将其作为新型多孔血管支架、骨骼肌修复支架、神经修复导管与骨缺损填充物等。可预见随着技术和材料的不断发展,形状记忆聚合物在组织工程领域的应用将更加成熟。
关键词： 形状记忆聚合物;  组织工程;  3D支架    
Abstract:

Shape memory polymers are smart materials composed of a stationary phase and a reversible phase that induce shape change under external stimulus conditions. Compared with traditional shape memory alloys and ceramics, it has specific biodegradability, higher mechanical property control space, stronger deformation recovery ability and better biocompatibility. Due to the material properties, the application of shape memory polymers in the field of tissue engineering has become more and more extensive in recent years, including vascular tissue, skeletal muscle tissue, nerve tissue and bone tissue. In this paper, the experimental innovations, technological breakthroughs and application developments of shape memory polymers in various fields of tissue engineering have been reviewed in recent years, for example, as novel porous vascular stents, skeletal muscle repair stents, nerve repair catheters and bone defect fillers. It is foreseeable that with the continuous development of technology and materials, the application of shape memory polymers in the field of tissue engineering will be more mature.
Key words: Shape memory polymers    Tissue engineering    3D scaffolds
收稿日期: 2018-06-21 出版日期: 2019-01-10
ZTFLH:  Q819  
基金资助: * 国家自然科学基金(81570287);* 山东省重点研发计划(2018GGX102016);* 青岛市民生科技计划(16-6-2-9-nsh)
通讯作者: 宿烽     E-mail: sufengvip@126.com
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郗来顺
云鹏
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邢泉生
陈阳生
宿烽

引用本文:

郗来顺,云鹏,王元斗,张冠宏,邢泉生,陈阳生,宿烽. 形状记忆聚合物在组织工程中的应用 *[J]. 中国生物工程杂志, 2018, 38(12): 76-81.

XI Lai-shun,YUN Peng,WANG Yuan-dou,ZHANG Guan-hong,XING Quan-sheng,CHEN Yang-sheng,SU Feng. Application of Shape Memory Polymer in Tissue Engineering. China Biotechnology, 2018, 38(12): 76-81.

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https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20181210    或    https://manu60.magtech.com.cn/biotech/CN/Y2018/V38/I12/76

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