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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2018, Vol. 38 Issue (9): 88-93    DOI: 10.13523/j.cb.20180913
综述     
铜绿假单胞菌Ⅵ型分泌系统的研究进展 *
方雪瑶,胡龙华,杭亚平,俞凤,陈艳慧,钟桥石()
南昌大学第二附属医院检验科 江西省检验医学重点实验室 南昌 330006
Research Progress of Type VI Secretion System in Pseudomonas aeruginosa
Xue-yao FANG,Long-hua HU,Ya-ping HANG,Feng YU,Yan-hui CHEN,Qiao-shi ZHONG()
Department of Clinical Laboratory Medicine,the Second Affiliated Hospital of Nanchang University,Key Laboratory of Laboratory Medicine in Jiangxi Province,Nanchang 330006,China
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摘要：

铜绿假单胞菌是一种能引起多部位急、慢性感染且难以用抗生素控制的机会致病菌,近年来已成为院内感染的主要致病菌之一。大量研究表明,细菌将毒力因子精准输送至宿主细胞是其致病的关键,分泌系统在这一过程中扮演重要作用,其中近期发现的Ⅵ型分泌系统(type VI secretion system,T6SS)在铜绿假单胞菌与宿主间的相互作用和促进生物膜的形成等机制中发挥重要作用,已引起国内外学者高度关注。着重对铜绿假单胞菌T6SS的结构组成、效应功能和调节机制等相关研究进行简要综述,旨在为铜绿假单胞菌感染患者的治疗提供新策略。
关键词： 铜绿假单胞菌;  Ⅵ型分泌系统;  效应蛋白    
Abstract:

In recent years, Pseudomonas aeruginosa has become one of the main pathogens of nosocomial infections, which is an opportunistic pathogen can cause acute or chronic multiple infections and is hard to be controlled by antibiotics. Studies have shown that the key to pathogenicity is the precise delivery of virulence factors to host cells by bacteria, while the secretory system plays an important role in this process. Among them, the recently discovered type VI secretion system (T6SS) is a type of secretion system that has drawn great attention from domestic and foreign,which plays an important role not only in the interaction between Pseudomonas aeruginosa and the host but also in the mechanism of promoting biofilm formation. Focusing on the studies of the structure, functions and regulatory mechanisms of Pseudomonas aeruginosa T6SS, a brief review was conducted to provide a new strategy for the treatment of patients with Pseudomonas aeruginosa infection.
Key words: Pseudomonas aeruginosa    Type VI secretion system    Effectors
收稿日期: 2018-03-29 出版日期: 2018-10-12
基金资助: * 江西省青年自然科学基金项目(20171BAB2150798);江西省教育厅一般项目(GJJ160172)
通讯作者: 钟桥石     E-mail: zhong20000947@sina.com
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方雪瑶
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陈艳慧
钟桥石

引用本文:

方雪瑶,胡龙华,杭亚平,俞凤,陈艳慧,钟桥石. 铜绿假单胞菌Ⅵ型分泌系统的研究进展 *[J]. 中国生物工程杂志, 2018, 38(9): 88-93.

Xue-yao FANG,Long-hua HU,Ya-ping HANG,Feng YU,Yan-hui CHEN,Qiao-shi ZHONG. Research Progress of Type VI Secretion System in Pseudomonas aeruginosa. China Biotechnology, 2018, 38(9): 88-93.

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https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20180913    或    https://manu60.magtech.com.cn/biotech/CN/Y2018/V38/I9/88

图1  T6SS的结构及装配示意图(改编自参考文献[19])
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