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过表达亚甲基四氢叶酸脱氢酶对高山被孢霉脂质合成的影响 * |
汪企再,王鸿超(),陈海琴,赵建新,张灏,陈卫,陈永泉 |
江南大学食品学院 无锡 214122 |
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Effects of MTHFD1 Overexpression on Lipid Synthesis in the Oleaginous Fungus, Mortierella alpina |
Qi-zai WANG,Hong-chao WANG(),Hai-qin CHEN,Jian-xin ZHAO,Hao ZHANG,Wei CHEN,Yong-quan CHEN |
School of Food Science and Technology, Jiangnan University, Wuxi 214122, China |
引用本文:
汪企再,王鸿超,陈海琴,赵建新,张灏,陈卫,陈永泉. 过表达亚甲基四氢叶酸脱氢酶对高山被孢霉脂质合成的影响 *[J]. 中国生物工程杂志, 2018, 38(9): 12-18.
Qi-zai WANG,Hong-chao WANG,Hai-qin CHEN,Jian-xin ZHAO,Hao ZHANG,Wei CHEN,Yong-quan CHEN. Effects of MTHFD1 Overexpression on Lipid Synthesis in the Oleaginous Fungus, Mortierella alpina. China Biotechnology, 2018, 38(9): 12-18.
链接本文:
https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20180902
或
https://manu60.magtech.com.cn/biotech/CN/Y2018/V38/I9/12
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[1] |
Wang H, Yang B, Hao G , et al. Biochemical characterization of the tetrahydrobiopterin synthesis pathway in the oleaginous fungus Mortierella alpina. Microbiology-Sgm, 2011,157(Pt11):3059-3070.
doi: 10.1099/mic.0.051847-0
|
[2] |
Nisha A, Venkateswaran G . Effect of culture variables on mycelial arachidonic acid production by Mortierella alpina. Food and Bioprocess Technology, 2011,4(2):232-240.
doi: 10.1007/s11947-008-0146-y
|
[3] |
Ratledge C . Fatty acid biosynthesis in microorganisms being used for single cell oil production. Biochimie, 2004,86(11):807-815.
doi: 10.1016/j.biochi.2004.09.017
pmid: 15589690
|
[4] |
Maehre H K, Jensen I J, Elvevoll E O , et al. Omega-3 fatty acids and cardiovascular diseases: effects, mechanisms and dietary relevance. International Journal of Molecular Sciences, 2015,16(9):22636-22661.
doi: 10.3390/ijms160922636
pmid: 4613328
|
[5] |
Sakuradani E, Abe T, Iguchi K , et al. A novel fungal omega3-desaturase with wide substrate specificity from arachidonic acid-producing Mortierella alpina 1S-4. Applied Microbiology and Biotechnology, 2005,66(6):648-654.
doi: 10.1007/s00253-004-1760-x
|
[6] |
Sakuradani E, Kobayashi M, Ashikari T , et al. Identification of delta12-fatty acid desaturase 225 from arachidonic acid-producing mortierella fungus by heterologous expression in the yeast Saccharomyces cerevisiae and the fungus Aspergillus oryzae. European Journal of Biochemistry, 1999,261(3):812-820.
doi: 10.1046/j.1432-1327.1999.00333.x
|
[7] |
Kaufman S . New tetrahydrobiopterin-dependent systems. Annual Review of Nutrition, 1993,13(13):261-286.
doi: 10.1146/annurev.nu.13.070193.001401
|
[8] |
Fan J, Ye J, Kamphorst J J , et al. Quantitative flux analysis reveals folate-dependent NADPH production. Nature, 2014,510(7504):298-302.
doi: 10.1038/nature13236
pmid: 24805240
|
[9] |
Lewis C A, Parker S J, Fiske B P , et al. Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells. Molecular Cell, 2014,55(2):253-263.
doi: 10.1016/j.molcel.2014.05.008
pmid: 24882210
|
[10] |
Ratledge C . The role of malic enzyme as the provider of NADPH in oleaginous microorganisms: a reappraisal and unsolved problems. Biotechnology Letters, 2014,36(8):1557-1568.
doi: 10.1007/s10529-014-1532-3
|
[11] |
Wang L, Chen W, Feng Y , et al. Genome characterization of the oleaginous fungus mortierella alpina. PLoS One, 2011,6(12):e28319.
doi: 10.1371/journal.pone.0028319
pmid: 3234268
|
[12] |
Pawelek P D , MacKenzie R E . Methylenetetrahydrofolate dehydrogenase-cyclohydrolase from Photobacterium phosphoreum shares properties with a mammalian mitochondrial homologue. Biochimica Et Biophysica Acta-Protein Structure and Molecular Enzymology, 1996,1296(1):47-54.
|
[13] |
Patel H, Christensen K E, Mejia N , et al. Mammalian mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase derived from a trifunctional methylenetetrahydrofolate dehydrogenase-cyclohydrolase-synthetase. Archives of Biochemistry and Biophysics, 2002,403(1):145-148.
doi: 10.1016/S0003-9861(02)00203-5
|
[14] |
Bolusani S, Young B A, Cole N A , et al. Mammalian MTHFD2L encodes a mitochondrial methylenetetrahydrofolate dehydrogenase isozyme expressed in adult tissues. Journal of Biological Chemistry, 2011,286(7):5166-5174.
doi: 10.1074/jbc.M110.196840
|
[15] |
王鸿超, 刘媛, 顾震南 , 等. 叶酸代谢抑制剂对小鼠骨髓基质细胞增殖和分化的影响. 食品科学, 2016,37(15):215-220.
doi: 10.7506/spkx1002-6630-201615036
|
|
Wang H C, Liu Y, Gu Z N , et al. Effect of folate metabolism inhibitor on proliferation and differentiation of mouse marrow stromal cells. Food Science, 2016,37(15):215-220.
doi: 10.7506/spkx1002-6630-201615036
|
[16] |
Chen H, Hao G, Wang L , et al. Identification of a critical determinant that enables efficient fatty acid synthesis in oleaginous fungi. Scientific Reports, 2015,5(1):1124-1129.
|
[17] |
Bligh E G, Dyer W J . A rapid Method oftotal lipid extraction and purification. Canadian Journal of Biochemistry & Physiology, 1959,37(8):911-917.
|
[18] |
Wang H, Chen H, Hao G , et al. Role of the phenylalanine-hydroxylating system in aromatic substance degradation and lipid metabolism in the oleaginous fungus Mortierella alpina. Applied and Environmental Microbiology, 2013,79(10):3225-3233.
doi: 10.1128/AEM.00238-13
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