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在肝癌细胞SK-Hep1中沉默STAT3基因增强sorafenib疗效的初步研究* |
谢琳娜1,2,曾燕华2,柯伙钊1,何文胜1,郑敏2,林德馨2*() |
1 福建生物工程职业技术学院食品与生物工程系 福州 350003 2 福建医科大学基础医学院 福州 350108 |
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A Preliminary Study on Enhancing the Efficacy of Sorafenib by Silencing STAT3 Gene in SK-Hep1 Cells |
Lin-na XIE1,2,Yan-hua ZENG2,Huo-zhao KE1,Wen-sheng HE1,Min ZHENG2,De-xin LIN2*() |
1 Department of Food and Bioengineering, Fujian Vocational College of Bioengineering,Fuzhou 350003, China 2 College of Basic Medical Sciences,Fujian Medical University, Fuzhou 350108, China |
引用本文:
谢琳娜,曾燕华,柯伙钊,何文胜,郑敏,林德馨. 在肝癌细胞SK-Hep1中沉默STAT3基因增强sorafenib疗效的初步研究*[J]. 中国生物工程杂志, 2017, 37(12): 8-13.
Lin-na XIE,Yan-hua ZENG,Huo-zhao KE,Wen-sheng HE,Min ZHENG,De-xin LIN. A Preliminary Study on Enhancing the Efficacy of Sorafenib by Silencing STAT3 Gene in SK-Hep1 Cells. China Biotechnology, 2017, 37(12): 8-13.
链接本文:
https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20171202
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https://manu60.magtech.com.cn/biotech/CN/Y2017/V37/I12/8
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[1] |
Wilhelm S, Carter C, Lynch M, et al.Discovery and development of sorafenib: a multikinase inhibitor for treating cancer. Nature Reviews Drug Discovery, 2006,5(10):835-844.
doi: 10.1038/nrd2130
pmid: 17016424
|
[2] |
Llovet J M, Ricci S, Mazzaferro V, et al.Sorafenib in advanced hepatocellular carcinoma. The New England Journal of Medicine, 2008, 359(4):378-390.
doi: 10.1056/NEJMoa0708857
|
[3] |
Maluccio M, Covey A.Recent progress in understanding, diagnosing, and treating hepatocellular carcinoma. CA: A Cancer Journal for Clinicians, 2012, 62(6):394-399.
doi: 10.3322/caac.21161
pmid: 23070690
|
[4] |
Levy D E, Inghirami G.STAT3: a multifaceted oncogene. Proc Natl Acad Sci USA, 2006, 103(27):10151-10152.
doi: 10.1073/pnas.0604042103
pmid: 16801534
|
[5] |
Zimmers T A, Fishel M L, Bonetto A.STAT3 in the systemic inflammation of cancer cachexia. Seminars in Cell & Developmental Biology, 2016, 54:28-41.
doi: 10.1016/j.semcdb.2016.02.009
pmid: 4867234
|
[6] |
He G, Karin M.NF-kappaB and STAT3 - key players in liver inflammation and cancer. Cell Research, 2011, 21(1):159-168.
doi: 10.1038/cr.2010.183
pmid: 21187858
|
[7] |
Sanchez A, Nagy P. Thorgeirsson S S.STAT-3 activity in chemically-induced hepatocellular carcinoma. European Journal of Cancer, 2003, 39(14):2093-2098.
doi: 10.1016/S0959-8049(03)00393-9
pmid: 12957465
|
[8] |
Moh A, Iwamoto Y, Chai G X, et al.Role of STAT3 in liver regeneration: survival, DNA synthesis, inflammatory reaction and liver mass recovery. Laboratory Investigation, 2007, 87(10):1018-1028.
doi: 10.1038/labinvest.3700630
pmid: 17660847
|
[9] |
Kiprianova I, Remy J, Milosch N, et al.Sorafenib sensitizes glioma cells to the BH3 mimetic ABT-737 by targeting MCL1 in a STAT3-dependent manner. Neoplasia, 2015, 17(7):564-573.
doi: 10.1016/j.neo.2015.07.003
pmid: 26297434
|
[10] |
Su T H, Shiau C W, Jao P, et al.Sorafenib and its derivative SC-1 exhibit antifibrotic effects through signal transducer and activator of transcription 3 inhibition. Proc Natl Acad Sci USA, 2015, 112(23):7243-7248.
doi: 10.1073/pnas.1507499112
pmid: 26039995
|
[11] |
Wang C Y, Chao T T, Tai W T, et al.Signal transducer and activator of transcription 3 as molecular therapy for non-small-cell lung cancer. Journal of Thoracic Oncology, 2014, 9(4):488-496.
doi: 10.1097/JTO.0000000000000107
pmid: 24736071
|
[12] |
Pichard D C, Cardones A R, Chu E Y, et al.Sorafenib-induced eruption mimicking erythema multiforme. JAMA Dermatology, 2016, 152(2):227-228.
doi: 10.1001/jamadermatol.2015.2930
pmid: 26422655
|
[13] |
郑敏, 谢琳娜, 曾燕华,等. CD44、CD133及EpCAM与肝癌细胞成瘤性及耐药性的相关性. 中国老年学杂志, 2015, 35(23):6668-6670.
|
|
Zheng M, Xie L N, Zeng Y H, et al. Correlation of CD44,CD133 an EpCAM with tumorigenicity and sorafenis resistance of liver cancer cells. Chinese Journal of Gerontology, 2015,35(23):6668-6670.
|
[14] |
Rahmani M, Davis E M, Bauer C, et al.Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation. The Journal of Biological Chemistry, 2005, 280(42):35217-35227.
doi: 10.1074/jbc.M506551200
pmid: 16109713
|
[15] |
Yu C, Bruzek L M, Meng X W, et al.The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006. Oncogene, 2005, 24(46):6861-6869.
doi: 10.1038/sj.onc.1208841
|
[16] |
Yang F, Van Meter T E, Buettner R, et al. Sorafenib inhibits signal transducer and activator of transcription 3 signaling associated with growth arrest and apoptosis of medulloblastomas. Molecular Cancer Therapeutics, 2008, 7(11):3519-3526.
doi: 10.1158/1535-7163.MCT-08-0138
pmid: 19001435
|
[17] |
Yang F, Brown C, Buettner R, et al.Sorafenib induces growth arrest and apoptosis of human glioblastoma cells through the dephosphorylation of signal transducers and activators of transcription 3. Molecular Cancer Therapeutics, 2010, 9(4):953-962.
doi: 10.1158/1535-7163.MCT-09-0947
pmid: 20371721
|
[18] |
Li L, Wang H.Heterogeneity of liver cancer and personalized therapy. Cancer Letters, 2016, 379(2):191-197.
doi: 10.1016/j.canlet.2015.07.018
pmid: 26213370
|
[19] |
Hikita H, Takehara T, Shimizu S, et al.The Bcl-xL inhibitor, ABT-737, efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenib. Hepatology, 2010, 52(4):1310-1321.
doi: 10.1002/hep.23836
pmid: 20799354
|
[20] |
Casadei Gardini A, Tenti E, Masini C, et al.Multicentric survey on dose reduction/interruption of cancer drug therapy in 12 472 patients: indicators of suspected adverse reactions. Oncotarget, 2016, 7(26):40719-40724.
doi: 10.18632/oncotarget.8942
pmid: 27119511
|
[21] |
Tae-Yong H A, Shin Hwang, KI-Myeong Moon, et al.Sorafenib inhibits migration and invasion of hepatocellular carcinoma cells through suppression of matrix metalloproteinase expression. Anticancer Res, 2015,35(4):1967-1976.
pmid: 25862849
|
[22] |
Zeynep Firtina Karagonlar, Dogukan Koc, Evin Iscan, et al.Elevated hepatocyte growth factor expression as an autocrine c-Met activation mechanism in acquired resistance to sorafenib in hepatocellular carcinoma cells. Cancer Sci, 2016,107(4):407-416.
doi: 10.1111/cas.12891
pmid: 26790028
|
[23] |
Man-Hsin Hung, Wei-Tien Tai, Chung-Wai Shiau, et al.Downregulation of signal transducer and activator of transcription 3 by sorafenib: a novel mechanism for hepatocellular carcinoma therapy. World J Gastroenterol, 2014,20(41):15269-15274.
doi: 10.3748/wjg.v20.i41.15269
pmid: 25386075
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