| 综述 |
|
|
|
|
| 基因工程技术优化透明质酸生产的研究进展 |
| 郜娇娇, 杨树林 |
| 南京理工大学 南京 210094 |
|
| Advances in Optimization of Hyaluronic Acid Production by Genetic Engineering Technology |
| GAO Jiao-jiao, YANG Shu-lin |
| School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, China |
[1] Vigetti D, Karousou E, Viola M, et al. Hyaluronan:biosynthesis and signaling. Biochim Biophys Acta, 2014, 1840(8):2452-2459.
[2] Viola M, Vigetti D, Karousou E, et al. Biology and biotechnology of hyaluronan. Glycoconjugate Journal, 2015, 32(3):93-103.
[3] Anderegg U, Simon J C, Averbeck M. More than just a filler——the role of hyaluronan for skin homeostasis. Exp Dermatol, 2014, 23(5):295-303.
[4] Ammar T Y, Pereira T A, Mistura S L, et al. Viscosupplementation for treating knee osteoarthrosis:review of the literature. Rev Bras Ortop, 2015, 50(5):489-494.
[5] Mencucci R, Boccalini C, Caputo R, et al. Effect of a hyaluronic acid and carboxymethylcellulose ophthalmic solution on ocular comfort and tear-film instability after cataract surgery. J Cataract Refract Surg, 2015, 41(8):1699-1704.
[6] Nesti L J, Li W J, Shanti R M, et al. Intervertebral disc tissue engineering using a novel hyaluronic acid-nanofibrous scaffold (HANFS) amalgam. Tissue Eng Part A, 2008, 14(9):1527-1537.
[7] Robert L. Hyaluronan, a truly "youthful" polysaccharide. Its medical applications. Pathologie Biologie, 2015, 63(1):32-34.
[8] Ghosh S, Hoselton S A, Dorsam G P, et al. Hyaluronan fragments as mediators of inflammation in allergic pulmonary disease. Immunobiology, 2015, 220(5):575-588.
[9] De Oliveira J D, Carvalho L S, Gomes A M, et al. Genetic basis for hyper production of hyaluronic acid in natural and engineered microorganisms. Microb Cell Fact, 2016, 15(1):119.
[10] Blank L M, Hugenholtz P, Nielsen L K. Evolution of the hyaluronic acid synthesis (has) operon in Streptococcus zooepidemicus and other pathogenic streptococci. J Mol Evol, 2008, 67(1):13-22.
[11] Marcellin E, Steen J A, Nielsen L K. Insight into hyaluronic acid molecular weight control. Appl Microbiol Biotechnol, 2014, 98(16):6947-6956.
[12] Sheng J Z, Ling P X, Zhu X Q, et al. Use of induction promoters to regulate hyaluronan synthase and UDP-glucose-6-dehydrogenase of Streptococcus zooepidemicus expression in Lactococcus lactis:a case study of the regulation mechanism of hyaluronic acid polymer. J Appl Microbiol, 2009, 107(1):136-144.
[13] Aya K L, Stern R, Chen W Y. Hyaluronan in wound healing:rediscovering a major player.Wound Repair Regen, 2014, 22(5):579-593.
[14] Yuan P, Lv M, Jin P, et al. Enzymatic production of specifically distributed hyaluronan oligosaccharides. Carbohydr Polym, 2015, 129:194-200.
[15] Chen W Y, Marcellin E, Hung J, et al. Hyaluronan molecular weight is controlled by UDP-N-acetylglucosamine concentration in Streptococcus zooepidemicus. J Biol Chem, 2009, 284(27):18007-18014.
[16] Marcellin E, Nielsen L K, Abeydeera P, et al. Quantitative analysis of intracellular sugar phosphates and sugar nucleotides in encapsulated streptococci using HPAEC-PAD. Biotechnol J, 2009, 4(1):58-63.
[17] Tlapak-Simmons V L, Baggenstoss B A, Kumari K, et al. Kinetic characterization of the recombinant hyaluronan synthases from Streptococcus pyogenes and Streptococcus equisimilis. J Bio Chem, 1999, 274(7):4246-4253.
[18] Marcellin E, Chen W Y, Nielsen L K. Understanding plasmid effect on hyaluronic acid molecular weight produced by Streptococcus equi subsp. zooepidemicus. Metabolic Engineering, 2010, 12(1):62-69.
[19] Chen W Y, Marcellin E, Steen J A, et al. The role of hyaluronic acid precursor concentrations in molecular weight control in Streptococcus zooepidemicus. Mol Biotechnol, 2014, 56(2):147-156.
[20] Hmar R V, Prasad S B, Jayaraman G, et al. Chromosomal integration of hyaluronic acid synthesis (has) genes enhances the molecular weight of hyaluronan produced in Lactococcus lactis. Biotechnol J, 2014, 9(12):1554-1564.
[21] Swaminathan J, Ramachandran K B. Influence of competing metabolic processes on the molecular weight of hyaluronic acid synthesized by Streptococcus zooepidemicus. Biochemical Engineering Journal, 2010, 48(2):148-158.
[22] Jokela T A, Jauhiainen M, Auriola S, et al. Mannose inhibits hyaluronan synthesis by down-regulation of the cellular pool of UDP-N-acetylhexosamines. J Biol Chem, 2008, 283(12):7666-7673.
[23] Badle S S, Jayaraman G, Ramachandran K B. Ratio of intracellular precursors concentration and their flux influences hyaluronic acid molecular weight in Streptococcus zooepidemicus and recombinant Lactococcus lactis. Bioresour Technol, 2014, 163:222-227.
[24] Kumari K, Weigel P H. Molecular cloning, expression, and characterization of the authentic hyaluronan synthase from Group C Streptococcus equisimilis. J Biol Chem, 1997, 272(51):32539-32546.
[25] Jia Y N, Zhu J, Chen X F, et al. Metabolic engineering of Bacillus subtilis for the efficient biosynthesis of uniform hyaluronic acid with controlled molecular weights. Bioresour Technol, 2013, 132:427-431.
[26] Zhang L, Huang H, Wang H, et al. Rapid evolution of hyaluronan synthase to improve hyaluronan production and molecular mass in Bacillus subtilis. Biotechnol Lett, 2016, 38(12):2103-2108.
[27] Medina A P, Lin J L, Weigel P H. Hyaluronan synthase mediates dye translocation across liposomal membranes. BMC Biochemistry, 2012, 13(2):1-9.
[28] Weigel P H, Baggenstoss B A. Hyaluronan synthase polymerizing activity and control of product size are discrete enzyme functions that can be uncoupled by mutagenesis of conserved cysteines. Glycobiology, 2012, 22(10):1302-1310.
[29] Jeong E, Shim W Y, Kim J H. Metabolic engineering of Pichia pastoris for production of hyaluronic acid with high molecular weight. J Biotechnol, 2014, 185:28-36.
[30] Jin P, Kang Z, Yuan P, et al. Production of specific-molecular-weight hyaluronan by metabolically engineered Bacillus subtilis 168. Metab Eng, 2016, 35:21-30.
[31] DeAngelis P L, Oatman L C, Gay D F. Rapid chemoenzymatic synthesis of monodisperse hyaluronan oligosaccharides with immobilized enzyme reactors. J Biol Chem, 2003, 278(37):35199-35203.
[32] Boltje T J, Buskas T, Boons G J. Opportunities and challenges in synthetic oligosaccharide and glycoconjugate research. Nat Chem, 2009, 1(8):611-622.
[33] Chien L J, Lee C K. Enhanced hyaluronic acid production in Bacillus subtilis by coexpressing bacterial hemoglobin. Biotechnol Prog, 2007, 23(5):1017-1022.
[34] Prasad S B, Jayaraman G, Ramachandran K B. Hyaluronic acid production is enhanced by the additional co-expression of UDP-glucose pyrophosphorylase in Lactococcus lactis. Appl Microbiol Biotechnol, 2010, 86(1):273-283.
[35] Widner B, Behr R, Von Dollen S, et al. Hyaluronic acid production in Bacillus subtilis. Appl Environ Microbiol, 2005, 71(7):3747-3752.
[36] Izawa N, Serata M, Sone T, et al. Hyaluronic acid production by recombinant Streptococcus thermophilus. J Biosci Bioeng, 2011, 111(6):665-670.
[37] 张晋宇. 表达phbCAB基因对兽疫链球菌中乳酸及透明质酸产量的影响. 北京:清华大学生命科学与技术系, 2005. Zhang J Y. Effect of expressing PHB synthesis genes phbCAB gene on production of latate and hyaluronic acid by Streptococcus zooepidemicus. Beijing:Tsinghua University, Department of life science and technology, 2005.
[38] Wu X M, Gao H J, Tian G, et al. Transformation of Streptococcus zooepidemicus with genes responsible for polyhydroxybutrate synthesis. Tsinghua Science and Technology, 2002, 7(4):387-392.
[39] Chong B F, Nielsen L K. Amplifying the cellular reduction potential of Streptococcus zooepidemicus. J Biotechnol, 2003, 100(1):33-41.
[40] Kaur M, Jayaraman G. Hyaluronan production and molecular weight is enhanced in pathway-engineered strains of lactate dehydrogenase-deficient Lactococcus lactis. Metab Eng Commun, 2016, 3:15-23.
[41] Ma Z, Geng J, Yi L, et al. Insight into the specific virulence related genes and toxin-antitoxin virulent pathogenicity islands in swine streptococcosis pathogen Streptococcus equi ssp. zooepidemicus strain ATCC35246. BMC Genomics, 2013, 14:377.
[42] 刘玉川, 李宇兴, 赖永勤,等. 透明质酸生产菌溶血素S基因缺失突变菌株的构建及其特性. 微生物学报, 2016, 56(11):1755-1765. Liu Y C, Li Y X, Lai Y Q, et al. Construction and characterization of hemolysin S gene mutant strain producing hyaluronic acid. Acta Microbiologica Sinica, 2016, 56(11):1755-1765.
[43] Prasad S B, Ramachandran K B, Jayaraman G. Transcription analysis of hyaluronan biosynthesis genes in Streptococcus zooepidemicus and metabolically engineered Lactococcus lactis. Appl Microbiol Biotechnol, 2012, 94(6):1593-1607.
[44] Yu H, Stephanopoulos G. Metabolic engineering of Escherichia coli for biosynthesis of hyaluronic acid. Metab Eng, 2008, 10(1):24-32.
[45] Deangelist P L, Achyuthan A M. Yeast-derived recombinant DG42 protein of Xenopus can synthesize hyaluronan in vitro. J Biol Chem, 1996, 271(39):23657-23660.
[46] Cheng F, Gong Q, Yu H, et al. High-titer biosynthesis of hyaluronic acid by recombinant Corynebacterium glutamicum. Biotechnol J, 2016, 11(4):574-584.
[47] Sze J H, Brownlie J C, Love C A. Biotechnological production of hyaluronic acid:a mini review. Biotech, 2016, 6(1):67.
[48] Jin P, Zhang L, Yuan P, et al. Efficient biosynthesis of polysaccharides chondroitin and heparosan by metabolically engineered Bacillus subtilis. Carbohydr Polym, 2016, 140:424-432.
[49] Tlustá M, Krahulec J, Pepeliaev S. Production of hyaluronic acid by mutant strains of group C Streptococcus. Mol Biotechnol, 2013, 54(3):747-755. |
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
