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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志  2015, Vol. 35 Issue (6): 68-74    DOI: 10.13523/j.cb.20150611
综述     
琼脂糖在组织工程中的研究进展
罗思施1, 汤顺清2
1. 广州创尔生物技术股份有限公司 广州 510663;
2. 暨南大学生命科学技术学院 广州 510600
Research Progress of Agarose in Tissue Engineering
LUO Si-shi1, TANG Shun-qing2
1. Guangzhou Trauer Biotechnology CO., Ltd, Guangzhou 510663, China;
2. College of Life Sciences and Biotechnology, Jinan University, Guangzhou 510600, China
 全文: PDF(509 KB)   HTML
摘要:

琼脂糖是一种来源丰富、成本低廉的天然高分子材料,具有生物安全性和可降解性,利用其凝胶化现象可制成形状可塑的具有三维网络结构的凝胶。与其他天然材料相比,琼脂糖凝胶在机械性能上具有一定优势,如抗拉伸/压缩性、粘弹性、流变性等。其特殊的防粘连作用,使其必须与其他材料复合或者选用适宜的定型方式制成组织工程支架,以提高支架的组织相容性,用于填充、修复或者再生机体缺损组织。琼脂糖在组织工程领域的研究历史虽然不长,但在软骨、神经、骨、角膜和口腔黏膜等方面已经取得一些研究成果,其独特的微观结构和力学性能使其在软骨组织工程方面的研究最为广泛。目前,琼脂糖的组织工程研究离临床应用还有一段距离,材料制备和作用机理探索将是未来研究的重点。

关键词: 琼脂糖组织工程细胞相容性可降解性凝胶性能    
Abstract:

Agarose, which is resourceful and low-cost, is one of the natural high polymer materials with biosecurity and biodegradability. It can be made into gel with three-dimensional network structure and plastic shape. Comparing with other natural materials, agarose have advantages in mechanical properties, such as tensile strength, resistance to compression, viscoelasticity, rheological property and so on. On account of the property of anti-adhesion, agarose tissue engineering scaffold, which is for filling, repairing or regenerating defective tissue, must be composited with other materials or custom-made in suitable ways, in order to enhance its histocompatibility. Research progresses have been made in tissue engineering, although the research history of agarose is not so long. The properties of microstructure and mechanics make it a suitable material for tissue engineering of cartilage, nerve, bone, cornea, oral mucosa, especially in the field of cartilage. So far, there is a long distance between research and clinical usage, and scaffold preparation and mechanism study may be the research hotspots of agarose in the future.

Key words: Agarose    Tissue engineering    Cytocompatibility    Biodegradability    Gelation ability
收稿日期: 2015-02-27 出版日期: 2015-06-25
ZTFLH:  R-1  
基金资助:

广东省海洋经济创新发展区域示范专项(GD2012-B03-002)、广东省科技计划项目(2012B070800007)资助项目

通讯作者: 汤顺清     E-mail: tshunqt@jnu.edu.cn
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引用本文:

罗思施, 汤顺清. 琼脂糖在组织工程中的研究进展[J]. 中国生物工程杂志, 2015, 35(6): 68-74.

LUO Si-shi, TANG Shun-qing. Research Progress of Agarose in Tissue Engineering. China Biotechnology, 2015, 35(6): 68-74.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20150611        https://manu60.magtech.com.cn/biotech/CN/Y2015/V35/I6/68


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