技术与方法 |
|
|
|
|
基于HPV16 E7蛋白CTLs抗原肽的病毒样颗粒治疗性疫苗的构建 |
褚晓杰1,2,3, 李杨1,2,3, 龙琼1,2,3, 姚宇峰1,2,3, 孙文佳1,2,3, 黄惟巍1,2,3, 杨旭1,2,3, 刘存宝1,2,3, 马雁冰1,2,3 |
1. 中国医学科学院/北京协和医学院 医学生物学研究所 昆明 650118;
2. 云南省重大传染病疫苗研发重点实验室 昆明 650118;
3. 云南省重大传染病疫苗工程技术研究中心 昆明 650118 |
|
Development of a HPV16 E7 CTLs Peptides-based Virus-like Particle Therapeutic Vaccine |
CHU Xiao-jie1,2,3, LI Yang1,2,3, LONG Qiong1,2,3, YAO Yu-feng1,2,3, SUN Wen-jia1,2,3, HUANG Wei-wei1,2,3, YANG Xu1,2,3, Liu Cun-bao1,2,3, MA Yan-bing1,2,3 |
1. Institute of Medical Biology, Chinese Academy of Medical Science & Peking Union Medical College, Kunming 650118, China;
2. Yunnan Key Laboratory of Vaccine Research&Development on Severe Infectious Disease, Kunming 650118, China;
3. Yunnan Engineering Research Center of Vaccine Research and Development on Severe Infectious Disease, Kunming 650118, China |
引用本文:
褚晓杰, 李杨, 龙琼, 姚宇峰, 孙文佳, 黄惟巍, 杨旭, 刘存宝, 马雁冰. 基于HPV16 E7蛋白CTLs抗原肽的病毒样颗粒治疗性疫苗的构建[J]. 中国生物工程杂志, 2015, 35(2): 45-51.
CHU Xiao-jie, LI Yang, LONG Qiong, YAO Yu-feng, SUN Wen-jia, HUANG Wei-wei, YANG Xu, Liu Cun-bao, MA Yan-bing. Development of a HPV16 E7 CTLs Peptides-based Virus-like Particle Therapeutic Vaccine. China Biotechnology, 2015, 35(2): 45-51.
链接本文:
https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20150207
或
https://manu60.magtech.com.cn/biotech/CN/Y2015/V35/I2/45
|
[1] Parkin D M, Bray F, Ferlay J, et al.Global cancer statistics, 2002.CA Cancer J Clin,2005,55(2): 74-108.
[2] Bolhassani A, Mohit E, Rafati S.Different spectra of therapeutic vaccine development against HPV infections.Hum Vaccin,2009,5(10): 671-689.
[3] Niebler M, Qian X, Hofler D, et al.Post-translational control of IL-1beta via the human papillomavirus type 16 E6 oncoprotein: a novel mechanism of innate immune escape mediated by the E3-ubiquitin ligase E6-AP and p53.PLoS Pathog,2013,9(8): e1003536.
[4] Yu Y, Munger K.Human papillomavirus type 16 E7 oncoprotein inhibits the anaphase promoting complex/cyclosome activity by dysregulating EMI1 expression in mitosis.Virology,2013,446(1-2): 251-259.
[5] Jemon K, Young V, Wilson M, et al.An enhanced heterologous virus-like particle for human papillomavirus type 16 tumour immunotherapy.PLoS One,2013,8(6): e66866.
[6] Monroy-Garcia A, Gomez-Lim M A, Weiss-Steider B, et al.Immunization with an HPV-16 L1-based chimeric virus-like particle containing HPV-16 E6 and E7 epitopes elicits long-lasting prophylactic and therapeutic efficacy in an HPV-16 tumor mice model.Arch Virol,2014,159(2): 291-305.
[7] Pokorna D, Polakova I, Kindlova M, et al.Vaccination with human papillomavirus type 16-derived peptides using a tattoo device.Vaccine,2009,27(27): 3519-3529.
[8] Ressing M E, van Driel W J, Brandt R M, et al.Detection of T helper responses, but not of human papillomavirus-specific cytotoxic T lymphocyte responses, after peptide vaccination of patients with cervical carcinoma.J Immunother,2000,23(2): 255-266.
[9] Berzofsky J A, Ahlers J D, Janik J, et al.Progress on new vaccine strategies against chronic viral infections.J Clin Invest,2004,114(4): 450-462.
[10] Bolhassani A,Mohit E,Rafati S.Different spectra of therapeutic vaccine development against HPV infections.Hum Vaccin,2009,5(10):671-689.
[11] Schreurs M W, Kueter E W, Scholten K B, et al.A single amino acid substitution improves the in vivo immunogenicity of the HPV16 oncoprotein E7(11-20) cytotoxic T lymphocyte epitope.Vaccine,2005,23(31):4005-4010.
[12] Song Y C, Cheng H Y, Leng C H, et al.A novel emulsion-type adjuvant containing CpG oligodeoxynucleotides enhances CD8+ T-cell-mediated anti-tumor immunity.J Control Release,2014,173: 158-165.
[13] Klencke B, Matijevic M, Urban R G, et al.Encapsulated plasmid DNA treatment for human papillomavirus 16-associated anal dysplasia: a Phase I study of ZYC101.Clin Cancer Res,2002,8(5):1028-1037.
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
|
Shared |
|
|
|
|
|
Discussed |
|
|
|
|