中国生物工程杂志

[1] Siegel R, Ma J, Zou Z, et al. Cancer statistics, 2014. CA,2014,64(1):9-29.

[2] He G, Dhar D, Nakagawa H, et al. Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling,Cell,2013,155(2):384-396.

[3] 吴孟超,沈锋. 肝癌研究的现状和展望. 国外医学肿瘤学分册,2000, 27(1):17. Wu M C, Shen F. The present situation and prospects of research on liver cancer. Foreign Medical Sciences(cancer section), 2000, 27 (1): 17.

[4] Bonnet D, Dick J E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nature Medicine,1997,3(7):730-737.

[5] Al-Hajj M, Wicha M S, Benito-Hernandez A, et al. Prospective identification of tumorigenic breast cancer cells. Proceedings of the National Academy of Sciences, 2003, 100(7):3983-3988.

[6] O'Brien C A, Pollett A, Gallinger S, et al. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature,2006,445(7123):106-110.

[7] Singh S K, Hawkins C, Clarke I D, et al. Identification of human brain tumour initiating cells. Nature,2004, 432(7015):396-401.

[8] Reya T, Morrison S J, Clarke M F, et al. Stem cells, cancer, and cancer stem cells. Nature,2001, 414(6859):105-111.

[9] Visvader J E, Lindeman G J. Cancer stem cells: current status and evolving complexities. Cell Stem Cell,2012,10(6):717-728.

[10] Yamashita T, Wang X W. Cancer stem cells in the development of liver cancer. The Journal of Clinical Investigation,2013,123(5):1911-1918.

[11] Huang P, Qiu J, Li B, et al. Role of Sox2 and Oct4 in predicting survival of hepatocellular carcinoma patients after hepatectomy. Clinical Biochemistry,2011,44(8):582-589.

[12] Shan J, Shen J, Liu L, et al. Nanog regulates self-renewal of cancer stem cells through the insulin-like growth factor pathway in human hepatocellular carcinoma. Hepatology (Baltimore, Md),2012, 56(3):1004-1014.

[13] Singh S K, Clarke I D, Terasaki M, et al. Identification of a cancer stem cell in human brain tumors. Cancer Research,2003, 63(18):5821-5828.

[14] Kai K, Nagano O, Sugihara E, et al. Maintenance of HCT116 colon cancer cell line conforms to a stochastic model but not a cancer stem cell model. Cancer Science,2009,100(12):2275-2282.

[15] Tsuchiya A, Heike T, Fujino H, et al. Long-term extensive expansion of mouse hepatic stem/progenitor cells in a novel serum-free culture system. Gastroenterology,2005,128(7):2089-2104.

[16] Collura A, Marisa L, Trojan D, et al. Extensive characterization of sphere models established from colorectal cancer cell lines. Cellular and Molecular Life Sciences,2013, 70(4):729-742.

[17] Qiu X, Wang Z, Li Y, et al. Characterization of sphere-forming cells with stem-like properties from the small cell lung cancer cell line H446. Cancer Letters,2012,323(2):161-170.

[18] Zhang L, Jiao M, Li L, et al. Tumorspheres derived from prostate cancer cells possess chemoresistant and cancer stem cell properties. Journal of Cancer Research and Clinical Oncology,2012,138(4):675-686.

[19] Alimperti S, Lei P, Wen Y, et al. Serum-free spheroid suspension culture maintains mesenchymal stem cell proliferation and differentiation potential. Biotechnology Progress,2014,30(4):974-983.

[20] Reilly J, Ayis S, Ferrier I, et al. Thioridazine and sudden unexplained death in psychiatric in-patients. The British Journal of Psychiatry, 2002, 180(6):515-522.

[21] Huq Z U, Investigators R G. A trial of low doses of risperidone in the treatment of patients with first-episode schizophrenia, schizophreniform disorder, or schizoaffective disorder. Journal of Clinical Psychopharmacology, 2004, 24(2):220-224.

[22] Potkin S G, Thyrum P T, Alva G, et al. The safety and pharmacokinetics of quetiapine when coadministered with haloperidol, risperidone, or thioridazine. Journal of Clinical Psychopharmacology, 2002, 22(2):121-130.

[23] Choi A R, Kim J H, Yoon S. Thioridazine specifically sensitizes drug-resistant cancer cells through highly increase in apoptosis and P-gp inhibition. Tumor Biology, 2014,35(10):9831-9838.

[24] Kang S, Dong S M, Kim B R, et al. Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells. Apoptosis: An International Journal on Programmed Cell Death, 2012, 17(9):989-997.

[25] Sachlos E, Risueño R M, Laronde S, et al. Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells. Cell, 2012, 149(6):1284-1297.

[26] Cao L, Zhou Y, Zhai B, et al. Sphere-forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines. BMC Gastroenterology, 2011, 11(1):71.

[27] Lee T K W, Castilho A, Cheung V C H, et al. CD24⁺ Liver tumor-initiating cells drive self-renewal and tumor initiation through STAT3-mediated NANOG regulation. Cell Stem Cell, 2011, 9(1):50-63.

[28] Bilim V, Kasahara T, Hara N, et al. Role of XIAP in the malignant phenotype of transitional cell cancer (TCC) and therapeutic activity of XIAP antisense oligonucleotides against multidrug-resistant TCC in vitro. International Journal of Cancer, 2003, 103(1):29-37.

[29] Yu Z, Pestell T G, Lisanti M P, et al. Cancer stem cells. The International Journal of Biochemistry & Cell Biology, 2012, 44(12):2144-2151.

[30] Hanahan D, Weinberg R A. Hallmarks of cancer: the next generation. Cell, 2011, 144(5):646-674.

[31] Yang J, van Oosten A L, Theunissen T W, et al. Stat3 activation is limiting for reprogramming to ground state pluripotency. Cell Stem Cell, 2010, 7(3):319-328.

[32] Chen W, Shen X, Xia X, et al. NSC 74859-mediated inhibition of STAT3 enhances the anti-proliferative activity of cetuximab in hepatocellular carcinoma. Liver International,2012,32(1):70-77.

[33] Sun C, Sun L, Jiang K, et al. NANOG promotes liver cancer cell invasion by inducing epithelial-mesenchymal transition through NODAL/SMAD3 signaling pathway. Int J Biochem Cell Biol, 2013, 45(6):1099-1108.

[34] Silva J, Nichols J, Theunissen T W, et al. Nanog is the gateway to the pluripotent ground state, Cell, 2009, 138(4):722-737.

[35] Johansson H, Simonsson S. Core transcription factors, Oct4, Sox2 and Nanog, individually form complexes with nucleophosmin (Npm1) to control embryonic stem (ES) cell fate determination. Aging-Us, 2010,2(11):815-822.