组织器官三维构建及原位组织工程概念——组织工程连载之四

doi:10.13523/j.cb.20140817

中国生物工程杂志

2014, Vol. 34

Issue (8): 112-116 DOI: 10.13523/j.cb.20140817

讲座

组织器官三维构建及原位组织工程概念——组织工程连载之四

王佃亮

第二炮兵总医院药学部组织工程与再生医学实验室北京 100088

Three-dimensional Construction of Tissue Organ and Concept of in situ Tissue Engineering

WANG Dian-liang

Tissue Engineering and Regenerative Medicine Laboratory, The Second Artillery General Hospital, Beijing 100088, China

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摘要：

组织器官三维构建就是把种子细胞和支架材料结合而获得设计的组织或器官，属于组织工程的核心内容，也最能体现组织工程的技术水平，如血管、气管的构建。由于传统组织工程存在缺陷，Shimizu于1998年首先提出了原位组织工程的概念，它是运用组织工程学基本原理，通过各种方法诱导移植的外源性的种子细胞或内源性的缺损组织局部细胞发生迁移、增殖、分化形成新生组织修复缺损。原位组织工程最大的特点是不依赖体外的细胞培养装置——生物反应器。原位组织工程是传统离体组织工程的有益补充。离体组织工程仍具有广阔的发展前景。

关键词： 离体组织工程; 组织器官; 组织工程; 三维构建; 原位组织工程

Abstract:

Tissue organ three-dimensional construction is that seed cells are combined with scaffold material to obtain the designed tissue or organ, which is a main content of tissue engineering and can represent technological merits of tissue engineering, such as the construction of blood vessel and trachea. For the flaws of traditional tissue engineering, Shimizu firstly put forward the concept of in situ tissue engineering, which applies the basic principle of tissue engineering to develop new tissue to repair defects by means of the transplanted seed cells induced by every method or the migration, proliferation and differentiation of the local cells of endogenic defect tissues. The distinctive characteristic of in situ tissue engineering is that bioreactor, an in vitro cell culture apparatus, is independent. In situ tissue engineering is a beneficial supplement of traditional ex vivo tissue engineering, which still has vast potentials for future development.

Key words: Tissue organ Tissue engineering Three-dimensional construction In situ tissue engineering Ex vivo tissue engineering

收稿日期: 2014-07-15 出版日期: 2014-08-25

ZTFLH:

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通讯作者: 王佃亮，E-mail：wangdianliang@sina.com E-mail: wangdianliang@sina.com

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引用本文:

王佃亮. 组织器官三维构建及原位组织工程概念——组织工程连载之四[J]. 中国生物工程杂志, 2014, 34(8): 112-116.

WANG Dian-liang. Three-dimensional Construction of Tissue Organ and Concept of in situ Tissue Engineering. China Biotechnology, 2014, 34(8): 112-116.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20140817 或 https://manu60.magtech.com.cn/biotech/CN/Y2014/V34/I8/112

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