| 研究报告 |
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| 人甲状腺激素受体相互作用蛋白15的初步结晶实验及其在人组织表达的研究 |
| 王海波1,2, 叶雨佳1, 孟照辉1 |
1. 昆明医科大学第一附属医院 分子心血管病研究室 昆明 650032;
2. 北京军区总医院生物治疗中心 北京 100700 |
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| Preliminary Crystallization of Human Thyroid Hormone Receptor Interacting Protein 15 and Its Expression in Human Tissue |
| WANG Hai-bo1,2, YE Yu-jia1, MENG Zhao-hui1 |
1. Laboratory of Molecular Cardiology, Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China;
2. Biotherapy Center, The General Hospital of Beijing Military Command, Beijing 100700, China |
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[1] Dressel U, Thormeyer D, Altincicek B, et al. Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily. Mol Cell Biol, 1999, 19(5): 3383-3394.
[2] Azuma Y, Takada M, Maeda M, et al. The COP9 signalosome controls ubiquitinylation of ABCA1. Biochem Biophys Res Commun, 2009, 382(1): 145-148.
[3] Serino G, Su H, Peng Z, et al. Characterization of the last subunit of the arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex. Plant Cell, 2003, 15(3): 719-731.
[4] Yang X, Menon S, Lykke-Andersen K, et al. The COP9 signalosome inhibits p27(kip1) degradation and impedes G1-S phase progression via deneddylation of SCF Cul1. Curr Biol, 2002, 12(8): 667-672.
[5] Lykke-Andersen K, Schaefer L, Menon S, et al. Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death. Mol Cell Biol, 2003, 23(19): 6790-6797.
[6] Tenbaum S P, Papaioannou M, Reeb C A, et al. Alien inhibits E2F1 gene expression and cell proliferation. Biochim Biophys Acta, 2007, 1773(9): 1447-1454.
[7] Kob R, Baniahmad A, Escher N, et al. Detection and identification of transcription factors as interaction partners of alien in vivo. Cell Cycle, 2007, 6(8): 993-996.
[8] Groisman R, Polanowska J, Kuraoka I, et al. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. Cell, 2003, 113(3): 357-367.
[9] Moehren U, Papaioannou M, Reeb C A, et al. Alien interacts with the human androgen receptor and inhibits prostate cancer cell growth. Mol Endocrinol, 2007, 21(5): 1039-1048.
[10] Akiyama H, Sugiyama A, Uzawa K, et al. Implication of Trip15/CSN2 in early stage of neuronal differentiation of P19 embryonal carcinoma cells. Brain Res Dev Brain Res, 2003, 140(1): 45-56.
[11] Leal J F, Fominaya J, Cascón A, et al. Cellular senescence bypass screen identifies new putative tumor suppressor genes. Oncogene, 2008, 27(14): 1961-1970.
[12] 彭永德, 张新,宋怀东,等. 人甲状腺受体相互作用蛋白15基因全长cDNA的克隆及其特性. 中国生物化学与分子生物学报, 2001, 17(5): 563-568. Peng Y D, Zhang X, Song H D, et al. Full-length cDNA cloning and identification of the characteristics of human thyroid receptor interacting protein 15 gene. Chinese Journal of Biochemistry and Molecular Biology, 2001, 17(5): 563-568.
[13] Wu Z Y, Chen Y J, Yang T, et al. Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. PloS One, 2012, 7(8): e43997.
[14] Enchev R I, Schreiber A, Beuron F, et al. Structural insights into the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3. Structure, 2010, 18(4): 518-527.
[15] Goubeaud A, Knirr S, Renkawitz-Pohl R, et al. The Drosophila gene alien is expressed in the muscle attachment sites during embryogenesis and encodes a protein highly conserved between plants, drosophila and vertebrates. Mech Dev, 1996, 57(1): 59-68.
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