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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2020, Vol. 40 Issue (4): 91-96    DOI: 10.13523/j.cb.1910036
综述     
光交联水凝胶在组织工程中的研究进展
王元斗1,宿烽1,2*,李速明3,*()
1 青岛科技大学高性能聚合物研究院 青岛 266042
2 青岛科技大学化工学院 青岛 266042
3 法国蒙彼利埃大学欧洲膜研究院 蒙彼利埃
Research Progress of Photocrosslinked Hydrogel in Tissue Engineering
WANG Yuan-dou1,SU Feng1,2*,LI Su-ming3,*()
1 Institute of High Performance Polymers, Qingdao University of Science and Technology, Qingdao 266042, China
2 College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China
3 European Institute of Membranes, University of Montpellier, 34095 Montpellier Cedex, France
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摘要：

由于生物相容性、可降解性、与天然细胞外基质结构的相似性,水凝胶成为组织工程的研究热点与重点。基于原位形成和可注射性、与现有加工技术(3D打印、静电纺丝)的兼容性,光交联水凝胶在组织工程领域广泛应用。综述了近年来光交联水凝胶在组织工程领域的研究进展,包括其在软骨组织、骨组织、脂肪组织、牙周组织和皮肤组织方面的研究思路及应用进展,以期为后续光交联水凝胶作为组织工程支架的研究提供参考。
关键词： 光交联水凝胶;  组织工程;  细胞支架    
Abstract:

Due to the biocompatibility, degradability, and similarity to the structure of natural extracellular matrix, hydrogel has become a research hotspot and focus of tissue engineering. Based on in-situ formation and injectability, and compatibility with existing processing technologies (3D printing, electrospinning), photocrosslinked hydrogels are widely used in the field of tissue engineering. In this paper, recent advances in the field of tissue engineering in photocrosslinked hydrogels are reviewed, including new advances in cartilage, bone, adipose and periodontal tissues. The paper reviews the photocrosslinked hydrogels and provides relevant references for future research.
Key words: Photocrosslinked hydrogel    Tissue engineering    Cell scaffold
收稿日期: 2019-10-22 出版日期: 2020-05-18
ZTFLH:  Q819  
通讯作者: 李速明     E-mail: lisuming@hotmail.com
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王元斗
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引用本文:

王元斗,宿烽,李速明. 光交联水凝胶在组织工程中的研究进展[J]. 中国生物工程杂志, 2020, 40(4): 91-96.

WANG Yuan-dou,SU Feng,LI Su-ming. Research Progress of Photocrosslinked Hydrogel in Tissue Engineering. China Biotechnology, 2020, 40(4): 91-96.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.1910036    或    https://manu60.magtech.com.cn/biotech/CN/Y2020/V40/I4/91

化学名称 缩写 光源 可聚合单体 文献
1-[4-(2-羟基乙氧基)苯基]-2-羟基-2-甲基-1-丙酮 Irgacure 2959 紫外光 GelMA, MCS, n-armPEG-PCL-AC, SMH, Col-GMA, HA-MA, CLF [16] 、[20] 、[25] 、[26] 、[34] 、[35] 、[36] 、[37] 、[49] 、[50]
苯基-2,4,6-三甲基苯甲酰基次膦酸锂 LAP 紫外光,可见光 PEG-PCL-DA, GelMA, GelNB, GelSH [18] 、[21] 、[31] 、[41] 、[42] 、[43]
2',4',5',7'-四溴荧光素二钠盐 曙红Y 可见光 GelMA, PEGDA, PEGNB [13] 、[14] 、[19]
2-羟基-2-甲基苯丙酮 Irgacure 1173 紫外光 MCS, PEGDA, DMA, GelMA [15] 、[47]
核黄素 维生素B2 可见光 F-HA, MA-CMCS [17]
表1  常用的光引发剂种类和光源
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