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中国生物工程杂志

China Biotechnology
China Biotechnology  2010, Vol. 30 Issue (02): 100-104    DOI:
    
The Application of Gene Microarray in Detecting Pathogenic Bacteria
The State Key Laboratory of Pathogens and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences,Beijing 100071, China
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Abstract  

DNA microarray bears the advantages of fast, high-throughput, parallel-oriented, and has a broad application prospect in the detection of bacterial pathogens. One of the key step is how to select the appropriate target gene of bacteria. The bacterial ribosomal gene has been utilized as universal target gene; however, it has the shortage of non-specific hybridization. With more and more genome information and gene functions available, many more genes reveal better genus or species-specificity, such as virulence genes and resistance genes, which provide more specific targets for the detection of pathogenic bacteria using microarray. Therefore, microarray technology will be more sensitive, accurate, and will play a greater role in the study of pathogenic bacteria.



Key wordsPathogenic bacteria      Gene microarray      Universal gene      Specific gene     
Received: 21 October 2009      Published: 26 February 2010
Cite this article:

GAO Xin, WANG Jing-Lin. The Application of Gene Microarray in Detecting Pathogenic Bacteria. China Biotechnology, 2010, 30(02): 100-104.

URL:

https://manu60.magtech.com.cn/biotech/     OR     https://manu60.magtech.com.cn/biotech/Y2010/V30/I02/100

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