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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2020, Vol. 40 Issue (12): 75-81    DOI: 10.13523/j.cb.2007049
综述     
聚多巴胺的表面修饰功能在组织工程的应用进展*
严格,乔韡华,曹红,史嘉玮,董念国()
华中科技大学同济医学院附属协和医院心脏大血管外科 武汉 430022
Application of Surface Modification of Polydopamine in Tissue Engineering
YAN Ge,QIAO Wei-hua,CAO Hong,SHI Jia-wei,DONG Nian-guo()
Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430022,China
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摘要：

聚多巴胺作为贻贝的仿生材料,可由多巴胺在碱性环境中自发形成。由于其较好的黏附特性以及组织相容性,在生命科学等领域有着广泛的应用。将聚多巴胺对材料进行表面修饰,既可以保护材料免受强氧化剂、酸碱等外界的侵蚀,也可以通过表面改性赋予材料新的功能,使其在各领域发挥更好的作用。对聚多巴胺的制备原理、生物性能,以及近年来在组织工程领域(骨组织、软骨组织、硬脑膜组织、血管组织、耳组织)的运用进行综述,以期为后续聚多巴胺作为组织工程黏附材料的研究提供参考。
关键词： 聚多巴胺;  表面修饰;  组织工程    
Abstract:

As a biomimetic material of mussel, polydopamine can be formed spontaneously by dopamine in alkaline environment. Because of its good adhesion properties and histocompatibility, it has a wide range of applications in life sciences and other fields. Surface modification of the material with polydopamine can not only protect the material from external corrosion such as strong oxidants, acids and alkalis, but also give the material new functions through surface modification, making it play a better role in various fields. The preparation principle, biological properties of polydopamine and its application in tissue engineering (bone tissue, cartilage tissue, dural tissue, blood vessel tissue, ear tissue) in recent years are reviewed, in order to provide reference for the follow-up study of polydopamine as a tissue engineering adhesive material.
Key words: Polydopamine    Surface modification    Tissue engineering
收稿日期: 2020-07-29 出版日期: 2021-01-14
ZTFLH:  Q819  
基金资助: * 国家自然科学基金资助项目(81930052);国家自然科学基金资助项目(81900351)
通讯作者: 董念国     E-mail: dongnianguo@hotmail.com
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严格
乔韡华
曹红
史嘉玮
董念国

引用本文:

严格,乔韡华,曹红,史嘉玮,董念国. 聚多巴胺的表面修饰功能在组织工程的应用进展*[J]. 中国生物工程杂志, 2020, 40(12): 75-81.

YAN Ge,QIAO Wei-hua,CAO Hong,SHI Jia-wei,DONG Nian-guo. Application of Surface Modification of Polydopamine in Tissue Engineering. China Biotechnology, 2020, 40(12): 75-81.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2007049    或    https://manu60.magtech.com.cn/biotech/CN/Y2020/V40/I12/75

图1  PDA“真黑素”模型的合成原理图
图2  在材料表面涂覆PDA,并共价接枝含有胺、硫醇和咪唑等官能团的亲核分子
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