综述 |
|
|
|
|
干细胞改善糖尿病的分子机制及临床研究进展 |
陈飞,王晓冰,徐增辉(),钱其军() |
上海细胞治疗工程技术研究中心 上海 201800 |
|
Molecular Mechanism and Clinical Research Progress of Mesenchymal Stem Cells in the Treatment of Diabetes Mellitus |
CHEN Fei,WANG Xiao-bing,XU Zeng-hui(),QIAN Qi-jun() |
Shanghai Cell Therapy Engineering Technology Research Center, Shanghai 200000, China |
引用本文:
陈飞,王晓冰,徐增辉,钱其军. 干细胞改善糖尿病的分子机制及临床研究进展[J]. 中国生物工程杂志, 2020, 40(7): 59-69.
CHEN Fei,WANG Xiao-bing,XU Zeng-hui,QIAN Qi-jun. Molecular Mechanism and Clinical Research Progress of Mesenchymal Stem Cells in the Treatment of Diabetes Mellitus. China Biotechnology, 2020, 40(7): 59-69.
链接本文:
https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2001061
或
https://manu60.magtech.com.cn/biotech/CN/Y2020/V40/I7/59
|
[1] |
Zimmet P. Globalization,coca-colonization and the chronic disease epidemic: Can the doomsday scenario be averted. Journal of Internal Medicine, 2000,247(3):301-310.
doi: 10.1046/j.1365-2796.2000.00625.x
pmid: 10762445
|
[2] |
Amos A F, Mccarty D J, Zimmet P. The rising global burden of diabetes and its complications: estimates and projections to the year 2010. Diabetic Medicine, 1997,14(S5):S7-S85.
doi: 10.1002/(SICI)1096-9136(199712)14:5+<S7::AID-DIA522>3.3.CO;2-I
|
[3] |
King H, Aubert R E, Herman W H. Global burden of diabetes, 1995 2025: Prevalence, numerical estimates, and projections. Diabetes Care, 1998,21(9):1414-1431.
doi: 10.2337/diacare.21.9.1414
pmid: 9727886
|
[4] |
Shafrir E. Development and consequences of insulin resistance: lessons from animals with hyperinsulinaemia. Diabetes & Metabolism, 1996,22(2):122-131.
pmid: 8792092
|
[5] |
Benjamin E J, Virani S S, Callaway C W, et al. Heart disease and stroke statistics-2018 update: a report from the American Heart Association. Circulation. 2018,137(12):e67-e492.
doi: 10.1161/CIR.0000000000000558
pmid: 29386200
|
[6] |
Beckman J A, Creager M A, Libby P. Diabetes and atherosclerosis: epidemiology, pathophysiology, and management. JAMA. 2002,287(19):2570-2581.
doi: 10.1001/jama.287.19.2570
pmid: 12020339
|
[7] |
Margaret Chan. Global report on diabetes. [2020-06-25]. http://www.who.int/diabetes/global-report/en/. .
|
[8] |
WHO. Global Strategy on diet, physical activity and health. Scandinavian Journal of Nutrition, 2009,48(2):292-302.
|
[9] |
American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care, 2013,36(Suppl 1):S67-S74.
doi: 10.2337/dc13-S067
|
[10] |
International Diabetes Foundation. Diabetes Atlas 8th Edition. [2020-06-25]. http://www.dia-betesatlas.org.
|
[11] |
张波, 杨文英. 中国糖尿病流行病学及预防展望. 中华糖尿病杂志, 2019,11(1):7-10.
|
|
Zhang B, Yang W Y. Outlook for the epidemiology and prevention of diabetes in china. Chin J Diabetes Mellitus, 2019,11(1):7-10.
|
[12] |
Wang L, Gao P, Zhang M, et al. Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013. JAMA. 2017,317(24):2515-2523.
doi: 10.1001/jama.2017.7596
pmid: 28655017
|
[13] |
American Diabetes Association. Standards of medical care in diabetes 2019. Diabetes Care, 2019,42(Suppl 1):S1-S193.
doi: 10.2337/dc19-Sint01
pmid: 30559224
|
[14] |
Friedenstein A J, Petrakova K V, Kurolesova A I, et al. Heterotopic of bone marrow, analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation, 1968,6(2):230-247.
pmid: 5654088
|
[15] |
Anker P S, Scherjon S A, Kleijburg-van Dder K C, et al. Isolation of mesenchymal stem cells of fetal or maternal origin from human placenta. Stem Cells, 2004,22(7):1338-1345.
doi: 10.1634/stemcells.2004-0058
pmid: 15579651
|
[16] |
Zu P A, Zhu M, Mizuno H, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Engineering Part A, 2001,7(2):211-228.
|
[17] |
Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. Cytotherapy, 2006,8(4):315-317.
doi: 10.1080/14653240600855905
pmid: 16923606
|
[18] |
Uccelli A, Moretta L, Pistoia V. Mesenchymal stem cells in health and disease. Nature Reviews Immunology, 2008,8(9):726-736.
pmid: 19172693
|
[19] |
Kolb H, Mandrup-Poulsen T. The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation. Diabetologia, 2010,53(1):10-20.
doi: 10.1007/s00125-009-1573-7
pmid: 19890624
|
[20] |
Sun Y, Chen L, Hou X G, et al. Differentiation of bone marrow-derived mesenchymal stem cells from diabetic patients into insulin-producing cells in vitro. Chinese Medical Journal, 2007,120(9):771-776.
pmid: 17531117
|
[21] |
Khorsandi L, Khodadadi A, Nejad-Dehbashi F, et al. Three-dimensional differentiation of adipose-derived mesenchymal stem cells into insulin-producing cells. Cell and Tissue Research, 2015,361(3):745-753.
doi: 10.1007/s00441-015-2140-9
pmid: 25795142
|
[22] |
Gao F, Wu D Q, Hu Y H, et al. In vitro cultivation of islet-like cell clusters from human umbilical cord blood-derived mesenchymal stem cells. Translational Research, 2008,151(6):293-302.
pmid: 18514140
|
[23] |
Tang D Q, Wang Q, Burkhardt B R, et al. In vitro generation of functional insulin-producing cells from human bone marrow-derived stem cells, but long-term culture running risk of malignant transformation. Am J Stem Cell, 2012,1(2):114-127.
|
[24] |
Piran M, Enderami S E, Piran M, et al. Insulin producing cells generation by overexpression of miR-375 in adipose-derived mesenchymal stem cells from diabetic patients. Biologicals, 2017,46(5):23-28.
doi: 10.1016/j.biologicals.2016.12.004
|
[25] |
Van P P, Thi-My N P, Thai-Quynh N A, et al. Improved differentiation of umbilical cord blood-derived mesenchymal stem cells into insulin-producing cells by PDX-1 mRNA transfection. Differentiation, 2014,87(5):200-208.
pmid: 25201603
|
[26] |
Timper K, Seboek D, Eberhardt M, et al. Human adipose tissue-derived mesenchymal stem cells differentiate into insulin, somatostatin, and glucagon expressing cells. Biochemical & Biophysical Research Communications, 2006,341(4):1135-1140.
doi: 10.1016/j.bbrc.2006.01.072
pmid: 16460677
|
[27] |
Trivedi H L, Vanikar A V, Thakker U, et al. Human adipose tissue-derived mesenchymal stem cells combined with hematopoietic stem cell transplantation synthesize insulin. Transplantation Proceedings, 2008,40(4):1135-1139.
|
[28] |
Dave S D, Trivedi H L, Gopal S C, et al. Combined therapy of insulin-producing cells and haematopoietic stem cells offers better diabetic control than only haematopoietic stem cells’ infusion for patients with insulin-dependent diabetes. Bmj Case Reports, 2014,8(1):38-41.
|
[29] |
Thakkar U G, Trivedi H L, Vanikar A V, et al. Co-infusion of insulin-secreting adipose tissue-derived mesenchymal stem cells and hematopoietic stem cells: novel approach to management of type 1 diabetes mellitus. International Journal of Diabetes in Developing Countries, 2016,36(4):426-432.
doi: 10.1007/s13410-015-0409-x
|
[30] |
Shapiro A M. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. The New England Journal of Medicine, 2000,343(4):230-238.
doi: 10.1056/NEJM200007273430401
pmid: 10911004
|
[31] |
Ryan E A, Paty B W, Senior P A, et al. Five years follow up after clinical islet transplantation. Diabetes, 2005,54(7):2060-2069.
doi: 10.2337/diabetes.54.7.2060
pmid: 15983207
|
[32] |
Scharp D W, Lacy P E, Santiago J V, et al. Results of our first nine intraportal islet allografts in type 1, insulin-dependent diabetic patients. Transplantation, 1991,51(1):76-85.
doi: 10.1097/00007890-199101000-00012
pmid: 1987709
|
[33] |
Hayek A, Beattie G M, Cirulli V, et al. Growth factor matrix-induced proliferation of human adult beta-cells. Diabetes, 1995,44(12):1458-1460.
doi: 10.2337/diab.44.12.1458
pmid: 7589854
|
[34] |
Yoshihiko I, Takeshi A, Dausuke Y, et al. Hepatocyte growth factor is constitutively produced by donor-derived bone marrow cells and promotes regeneration of pancreatic beta-cells. Biochem Biophys Res Commun, 2005,333(1):273-282.
pmid: 15950193
|
[35] |
Hess D, Li L, Martin M, et al. Bone marrow-derived stem cells initiate pancreatic regeneration. Nature Biotechnology, 2003,21(7):763-770.
doi: 10.1038/nbt841
pmid: 12819790
|
[36] |
Park K S, Kim Y S, Kim J H, et al. Trophic molecules derived from human mesenchymal stem cells enhance survival, function, and angiogenesis of isolated islets after transplantation. Transplantation, 2010,89(5):509-517.
doi: 10.1097/TP.0b013e3181c7dc99
pmid: 20125064
|
[37] |
Yoshiaki O, Masahiro T, Naomasa K, et al. Combined transplantation of pancreatic islets and adipose tissue-derived stem cells enhances the survival and insulin function of islet grafts in diabetic mice. Transplantation, 2010,90(12):1366-1373.
doi: 10.1097/TP.0b013e3181ffba31
pmid: 21076379
|
[38] |
Wang H, Strange C, Nietert P J, et al. Autologous mesenchymal stem cell and islet cotransplantation: safety and efficacy. Stem Cells Translational Medicine, 2017,7(1):11-19.
doi: 10.1002/sctm.17-0139
pmid: 29159905
|
[39] |
Ryan J M, Barry F P, Murphy J M, et al. Mesenchymal stem cells avoid allogeneic rejection. Journal of Inflammation, 2005,2(1):8-19.
doi: 10.1186/1476-9255-2-8
|
[40] |
Vasandan A B, Jahnavi S, Shashank C, et al. Human mesenchymal stem cells program macrophage plasticity by altering their metabolic status via a PGE2-dependent mechanism. Scientific Reports, 2016,6(1):1-17.
doi: 10.1038/s41598-016-0001-8
pmid: 28442746
|
[41] |
Mittal M, Tiruppathi C, Nepal S, et al. TNFα-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury. Proc Natl Acad Sci USA, 2016,113(50):e8151-e8158.
doi: 10.1073/pnas.1614935113
pmid: 27911817
|
[42] |
Wang G, Cao K, Liu K, et al. Kynurenic acid, an IDO metabolite, controls TSG-6-mediated immunosuppression of human mesenchymal stem cells. Cell Death & Differentiation, 2018,25(7):1209-1223.
doi: 10.1038/s41418-017-0006-2
pmid: 29238069
|
[43] |
Selleri S, Bifsha P, Civini S, et al. Human mesenchymal stromal cell-secreted lactate induces M2-macrophage differentiation by metabolic reprogramming. Oncotarget, 2016,7(21):30193-30210.
doi: 10.18632/oncotarget.8623
pmid: 27070086
|
[44] |
Yang Q, Zheng C, Cao J, et al. Spermidine alleviates experimental autoimmune encephalomyelitis through inducing inhibitory macrophages. Cell Death and Differentiation, 2016,23(11):1850-1861.
doi: 10.1038/cdd.2016.71
pmid: 27447115
|
[45] |
Su J, Chen X, Huang Y, et al. Phylogenetic distinction of iNOS and IDO function in mesenchymal stem cell-mediated immunosuppression in mammalian species. Cell Death and Differentiation, 2014,21(3):388-396.
doi: 10.1038/cdd.2013.149
pmid: 24162664
|
[46] |
Aggarwal S. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood, 2005,105(4):1815-1822.
doi: 10.1182/blood-2004-04-1559
pmid: 15494428
|
[47] |
Chabannes D, Hill M, Merieau E, et al. A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells. Blood, 2007,110(10):3691-3694.
doi: 10.1182/blood-2007-02-075481
pmid: 17684157
|
[48] |
Cao W, Yang Y, Wang Z, et al. Leukemia inhibitory factor inhibits T helper 17 cell differentiation and confers treatment effects of neural progenitor cell therapy in autoimmune disease. Immunity, 2011,35(2):273-284.
pmid: 21835648
|
[49] |
Augello A, Tasso R, Negrini S, et al. Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway. European Journal of Immunology, 2005,35(5):1482-1490.
doi: 10.1002/eji.200425405
pmid: 15827960
|
[50] |
Sioud M, Mobergslien A, Boudabous A, et al. Evidence for the involvement of galectin-3 in mesenchymal stem cell suppression of allogeneic T-cell proliferation. Scandinavian Journal of Immunology, 2010,71(4):267-274.
doi: 10.1111/j.1365-3083.2010.02378.x
pmid: 20384870
|
[51] |
Hsu W T, Lin C H, Chiang B L, et al. Prostaglandin E-2 potentiates mesenchymal stem cell-induced IL-10(+) IFN-gamma(+) CD4(+) regulatory T cells to control transplant arteriosclerosis. The Journal of Immunology, 2013,190(5):2372-2380.
doi: 10.4049/jimmunol.1202996
pmid: 23359497
|
[52] |
Groh M E, Maitra B, Szekely E, et al. Human mesenchymal stem cells require monocyte-mediated activation to suppress alloreactive T cells. Experimental Hematology, 2005,33(8):928-934.
doi: 10.1016/j.exphem.2005.05.002
pmid: 16038786
|
[53] |
Corradiperini C, Santos T M, Nos C, et al. Co-transplantation of xenogeneic bone marrow-derived mesenchymal stem cells alleviates rejection of pancreatic islets in non-obese diabetic mice. Transplantation Proceedings, 2017,49(4):902-905.
|
[54] |
Ding Y, Xu D, Feng G, et al. Mesenchymal stem cells prevent the rejection of fully allogenic islet grafts by the immunosuppressive activity of matrix metalloproteinase-2 and -9. Diabetes, 2009,58(8):1797-1806.
doi: 10.2337/db09-0317
pmid: 19509016
|
[55] |
Yoshihiko I, Takeshi A, Dausuke Y, et al. Hepatocyte growth factor is constitutively produced by donor-derived bone marrow cells and promotes regeneration of pancreatic beta-cells. Biochem Biophys Res Commun, 2005,333(1):273-282.
doi: 10.1016/j.bbrc.2005.05.100
pmid: 15950193
|
[56] |
Movassat J, Saulnier C, Portha B. Insulin administration enhances growth of the cell mass in streptozotocin treated newborn rats. Diabetes, 1997,46(9):1445-1452.
pmid: 9287045
|
[57] |
Hao H J, Liu J J, Shen J. Multiple intravenous infusions of bone marrow mesenchymal stem cells reverse hyperglycemia in experimental type 2 diabetes rats. Biochemical and Biophysical Research Communications, 2013,436(3):418-423.
doi: 10.1016/j.bbrc.2013.05.117
pmid: 23770360
|
[58] |
Moshtagh P R, Emami S H, Sharifi A M. Differentiation of human adipose-derived mesenchymal stem cell into insulin-producing cells: an in vitro study. Journal of Physiology and Biochemistry, 2013,69(3):451-458.
doi: 10.1007/s13105-012-0228-1
pmid: 23271274
|
[59] |
Si Y, Zhao Y, Hao H, et al. Infusion of mesenchymal stem cells ameliorates hyperglycemia in type 2 diabetic rats: identification of a novel role in improving insulin sensitivity. Diabetes, 2012,61(6):1616-1625.
doi: 10.2337/db11-1141
pmid: 22618776
|
[60] |
Lee R H, Seo M J, Reger R L, et al. Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice. Proceedings of the National Academy of Sciences, 2006,103(46):17438-17443.
|
[61] |
Collombat P, Xu X, Ravassard P, et al. The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into α and subsequently β Cells. Cell, 2009,138(3):449-462.
doi: 10.1016/j.cell.2009.05.035
pmid: 19665969
|
[62] |
Chandravanshi B, Bhonde R R. Shielding engineered islets with mesenchymal stem cells enhance survival under hypoxia. Journal of Cellular Biochemistry, 2017. 118(9):2672-2683.
doi: 10.1002/jcb.25885
pmid: 28098405
|
[63] |
Ohkouchi S, Block G J, Katsha A M, et al. Mesenchymal stromal cells protect cancer cells from ROS-induced apoptosis and enhance the warburg effect by secreting STC1. Molecular Therapy, 2012,20(2):417-423.
doi: 10.1038/mt.2011.259
pmid: 22146344
|
[64] |
Li J, Li D, Liu X, et al. Human umbilical cord mesenchymal stem cells reduce systemic inflammation and attenuate LPS-induced acute lung injury in rats. Journal of Inflammation, 2012,9(1):9-33.
pmid: 22439901
|
[65] |
Lesley G E, Andrew J, Jerrold M O. Obesity, inflammation, and insulin resistance. New York: Springer, 2013: 1-23.
|
[66] |
Jurrissen T J, Dylan O T, Winn N C, et al. Endothelial dysfunction occurs independently of adipose tissue inflammation and insulin resistance in ovariectomized Yucatan miniature-swine. Adipocyte, 2018,7(1):35-44.
doi: 10.1080/21623945.2017.1405191
pmid: 29283284
|
[67] |
Chen T, Xing J, Liu Y. Effects of telmisartan on vascular endothelial function, inflammation and insulin resistance in patients with coronary heart disease and diabetes mellitus. Experimental and Therapeutic Medicine, 2018,15(1):909-913.
doi: 10.3892/etm.2017.5451
pmid: 29399098
|
[68] |
Bhakta H K, Paudel P, Fujii H, et al. Oligonol promotes glucose uptake by modulating the insulin signaling pathway in insulin-resistant HepG2 cells via inhibiting protein tyrosine phosphatase 1B. Archives of Pharmacal Research, 2017,40(11):1314-1327.
doi: 10.1007/s12272-017-0970-6
pmid: 29027136
|
[69] |
Si Y, Zhao Y, Hao H, et al. Infusion of mesenchymal stem cells ameliorates hyperglycemia in type 2 diabetic rats. Diabetes. 2012,61(6):1616-1625.
doi: 10.2337/db11-1141
pmid: 22618776
|
[70] |
Deng Z, Xu H, Zhang J, et al. Infusion of adipose derived mesenchymal stem cells inhibits skeletal muscle mitsugumin 53 elevation and thereby alleviates insulin resistance in type 2 diabetic rats. Molecular Medicine Reports, 2018. 17(6):8466-8474.
pmid: 29693163
|
[71] |
Shree N, Bhonde R R. Conditioned media from adipose tissue derived mesenchymal stem cells reverse insulin resistance in cellular models. Journal of Cellular Biochemistry, 2017. 118(8):2037-2043.
doi: 10.1002/jcb.25777
pmid: 27791278
|
[72] |
Voltarelli J C, Couri C, Stracieri A, et al. Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus. The Journal of the American Medical Association, 2007,297(14):1568-1576.
doi: 10.1001/jama.297.14.1568
pmid: 17426276
|
[73] |
Mesples A, Majeed N, Zhang Y, et al. Early immunotherapy using autologous adult stem cells reversed the effect of anti-pancreatic islets in recently diagnosed type 1 diabetes mellitus: preliminary results. Medical Science Monitor, 2013,19(14):852-857.
doi: 10.12659/MSM.889525
|
[74] |
Hu J, Yu X, Wang Z, et al. Long term effects of the implantation of Wharton’s jelly-derived mesenchymal stem cells from the umbilical cord for newly-onset type 1 diabetes mellitus. Endocrine Journal, 2013,60(3):347-357.
doi: 10.1507/endocrj.ej12-0343
pmid: 23154532
|
[75] |
Carlsson P O, Schwarcz E, Korsgren O. Preserved β-Cell function in type 1 diabetes by mesenchymal stromal cells. Diabetes. 2015,64(2):587-592.
doi: 10.2337/db14-0656
pmid: 25204974
|
[76] |
Cai J, Wu Z, Xu X, et al. Umbilical cord mesenchymal stromal cell with autologous bone marrow cell transplantation in established type 1 diabetes: A pilot randomized controlled open-label clinical study to assess safety and impact on insulin secretion. Diabetes Care, 2016,39(1):149-157.
doi: 10.2337/dc15-0171
pmid: 26628416
|
[77] |
Bhansali A, Upreti V, Khandelwal N, et al. Efficacy of autologous bone marrow-derived stem cell transplantation in patients with type 2 diabetes mellitus. Stem Cells and Development, 2009,18(10):1407-1416.
doi: 10.1089/scd.2009.0164
pmid: 19686048
|
[78] |
Hu J, Li C, Wang L, et al. Long term effects of the implantation of autologous bone marrow mononuclear cells for type 2 diabetes mellitus. Endocrine Journal, 2012,59(11):1031-1039.
doi: 10.1507/endocrj.ej12-0092
pmid: 22814142
|
[79] |
Hu J, Wang Y, Gong H, et al. Long term effect and safety of Wharton’s jelly-derived mesenchymal stem cells on type 2 diabetes. Experimental and Therapeutic Medicine, 2016,12(3):1857-1866.
pmid: 27588104
|
[80] |
Kong D, Zhuang X, Wang D, et al. Umbilical cord mesenchymal stem cell transfusion ameliorated hyperglycemia in patients with type 2 diabetes mellitus. Clinical Laboratory, 2014,60(12):1969-1976.
doi: 10.7754/clin.lab.2014.140305
pmid: 25651730
|
[81] |
Jiang R, Han Z, Zhuo G, et al. Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study. Frontiers of Medicine, 2011,5(1):94-100.
doi: 10.1007/s11684-011-0116-z
pmid: 21681681
|
[82] |
Purwito P, Wibisono S, Sutjahjo A, et al. Adipose derived mesenchymal stem cells for treatment tertiary failure diabetes mellitus type 2. Journal of Biomimetics, Biomaterials and Biomedical Engineering, 2017,31(3):91-95.
|
[83] |
Veres A, Faust A L, Bushnell H L, et al. Charting cellular identity during human in vitro β-cell differentiation. Nature, 2019,569(7756):368-373.
doi: 10.1038/s41586-019-1168-5
pmid: 31068696
|
[84] |
Velazco C L, Song J, Maxwell K G, et al. Acquisition of dynamic function in human stem cell derived β cells. Stem Cell Reports, 2019,12(2):351-365.
doi: 10.1016/j.stemcr.2018.12.012
pmid: 30661993
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
|
Shared |
|
|
|
|
|
Discussed |
|
|
|
|