脂肪组织外泌体与机体其他组织互作研究进展 <sup>*</sup>

doi:10.13523/j.cb.1908020

中国生物工程杂志

2020, Vol. 40

Issue (3): 111-116 DOI: 10.13523/j.cb.1908020

综述

脂肪组织外泌体与机体其他组织互作研究进展 ^*

吴佳韩¹,江霖¹,陈婷¹,孙加节²,张永亮²,习欠云^3,^**(

)

1 广东省动物营养调控重点实验室广州 510642
2 国家生猪种业工程技术中心广州 510642
3 华南农业大学动物科学学院广州 510642

Research on the Interaction between Adipose Tissue Exosomes and Other Tissues

WU Jia-han¹,JIANG Lin¹,CHEN Ting¹,SUN Jia-jie²,ZHANG Yong-liang²,XI Qian-yun^3,^**(

)

1 Guangdong Provincial Key Laboratory of Animal Nutrition Control, Guangzhou 510642,China
2 National Engineering Research Center For Breeding Swine Industry, Guangzhou 510642,China
3 College of Animal Science, South China Agricultural University, Guangzhou 510642, China

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摘要：

脂肪作为机体内最大的分泌器官,可以通过释放激素,细胞因子等调节其他的组织器官.近年来研究发现,脂肪组织可以释放外泌体并通过体液循环传递信号至其他组织器官,调节其靶器官的生理功能,且针对不同的靶器官,外泌体会产生不同的作用效果.机体的稳态是各组织间相互作用的结果,外泌体的发现,为脂肪组织与其他组织互作提供了稳定的物质基础,但是,脂肪外泌体的作用依旧存在着许多未知效果.从脂肪组织外泌体的发现,鉴定,以及脂肪外泌体与肝脏,肌肉和其他组织器官的相互作用等方面进行综述,为脂肪外泌体的研究提供理论依据,以便更好地探索生命的奥秘.

关键词： 脂肪组织; 外泌体; 信号传递

Abstract:

Fat, as the largest secretory organ in the body, can regulate other tissues and organs by releasing hormones and cytokines. In recent years, studies have found that adipose tissue can release the form of exosomes, transmit signals to other tissues and organs through the circulation of body fluids, and regulate the physiological functions of its target organs, such as regulating liver fat deposition, muscle glycogen synthesis, angiogenesis, and damage repair. Such functions, for different target organs, exosomes will have different effects. The homeostasis of the body is the result of interactions between tissues, and the discovery of exosomes provides a stable material basis for the interaction of adipose tissue with other tissues, and the role of fat exosomes still has many unknown effects. The identification of adipose tissue exosomes and the interaction of adipose exosomes on the liver, muscle, and other tissues and organs from recent experimental reports were reviewed, provide a theoretical basis for the study of fat exosomes, and better explore the mysteries of life.

Key words: Adipose tissue Exosomes Signal transmission

收稿日期: 2019-08-10 出版日期: 2020-04-18

ZTFLH:

Q493.5

基金资助: * 国家自然科学基金(31872435);广东省自然科学基金重点项目(2018B030311015)

通讯作者: 习欠云 E-mail: xqy0228@163.com

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引用本文:

吴佳韩,江霖,陈婷,孙加节,张永亮,习欠云. 脂肪组织外泌体与机体其他组织互作研究进展 ^*[J]. 中国生物工程杂志, 2020, 40(3): 111-116.

WU Jia-han,JIANG Lin,CHEN Ting,SUN Jia-jie,ZHANG Yong-liang,XI Qian-yun. Research on the Interaction between Adipose Tissue Exosomes and Other Tissues. China Biotechnology, 2020, 40(3): 111-116.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.1908020 或 https://manu60.magtech.com.cn/biotech/CN/Y2020/V40/I3/111

图1 脂肪外泌体与肝脏,肌肉的作用关系[22]

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