Abstract Fibroblast growth factor 21（FGF21）is a novel fatty metabolic regulator. FGF-21 mRNA is most abundantly expressed in the liver. FGF21 can stimulate lipolysis in white adipose tissue and ketogenesis in liver，stimulate glucose uptake in adipocytes，increase insulin level，and delay the development of adenomas. We also find that the development of FGF-21 for the treatment of diabetes and other metabolic diseases will give us the foundation for further study.
