Recent Research Progresses of Membrane Separation Technology Used for Oligosaccharides Preparation and Separation

doi:10.13523/j.cb.2109023

China Biotechnology

2022, Vol. 42

Issue (4): 102-110 DOI: 10.13523/j.cb.2109023

Recent Research Progresses of Membrane Separation Technology Used for Oligosaccharides Preparation and Separation

NING Li-min^1,²,ZHU Ben-wei^2,^**(

),YAO Zhong²,SUN Yun²

1 School of Medicine and Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China
2 College of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China

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Abstract

The oligosaccharides are low-molecular-weights molecules degraded from polysaccharides. They possessed versatile physiological activities such as antioxidant, antitumor, antivirus and immune regulatory activities and have become the focus of functional food researches. Recently, the separation and preparation of oligosaccharides mainly used ion exchange chromatography, gel permeation chromatography and their union methods. However, these methods have disadvantages such as long separation time, high preparation costs and difficulty for large scale applications. The membrane separation technology can realize the separation of bi-components or multi-components based on the selective permeation process. It possessed several advantages such as easy operation, good separation effects, high efficiency and low energy consuming. Especially, it could be directly converted into large scale industrial applications and therefore it holds great potential for separation and preparation of oligosaccharides. The review systematically summarized the recent advances on the classification, separation operations and applications of membrane separation technology in oligosaccharides separation. In addition, it also discussed the challenges of membrane separation technology in applications of oligosaccharides separation processes.

Key words： Membrane separation Oligosaccharides Microfiltration Ultrafiltration Nanofiltration

Received: 08 September 2021 Published: 05 May 2022

ZTFLH:

TS225.4

Corresponding Authors: Ben-wei ZHU E-mail: zhubenwei@njtech.edu.cn

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	Li-min NING
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	Yun SUN

Cite this article:

NING Li-min,ZHU Ben-wei,YAO Zhong,SUN Yun. Recent Research Progresses of Membrane Separation Technology Used for Oligosaccharides Preparation and Separation. China Biotechnology, 2022, 42(4): 102-110.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.2109023 OR https://manu60.magtech.com.cn/biotech/Y2022/V42/I4/102

Fig.1 The aperture size and separation range of commonly used membrane

Table 1 The examples of microfiltration applications in oligosaccharides purification

Table 2 The examples of ultrafiltration applications in oligosaccharides purification

Table 3 The examples of nanofiltration applications in oligosaccharides purification


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