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Research Progress on the Quorum Sensing in the Dynamic Metabolic Regulation |
XUE Yan-ting,WU Sheng-bo,XU Cheng-yang,YUAN Bo-xin,YANG Shu-juan,LIU Jia-heng,QIAO Jian-jun,ZHU Hong-ji() |
Key Laboratory of the Ministry of Education on Bio-engineering System, School of Chernical Engineering and Technology, Tianjin University, Synthetic Biology Platform of Tianjin Chemical Industry Collaborative Innovation Center, Tianjin 300072, China |
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Abstract Quorum sensing is a special dynamic metabolic regulation mechanism. It is an environmental signal sensing system used by bacteria to monitor their own population densities. In recent years, with the vigorous development of synthetic biology, breakthroughs have also been made in the artificially synthesized flora and mixed bacteria co-culture technology based on stable flora relations. The quorum sensing system can achieve the purpose of autonomously controlling the relationship between bacteria and bacteria, and its research and application in metabolic engineering has received more and more attention. Based on the overview of quorum sensing, this paper summarizes the dynamic metabolic regulation of single bacteria based on quorum sensing; at the same time, research progress in the dynamic regulation of quorum sensing between Gram-negative and Gram-positive bacteria and co-cultivation is reviewed. In order to provide some suggestions and help for other quorum sensing applications.
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Received: 06 January 2020
Published: 23 June 2020
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Corresponding Authors:
Hong-ji ZHU
E-mail: zhj@tju.edu.cn
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