| Orginal Article |
|
|
|
|
| Research Progress of Fibroblast Growth Factor 5 |
YANG Dan1,TIAN Hai-shan2,LI Xiao-kun1,2,**( ) |
1 College of life and Environmental Science, Wenzhou University, Wenzhou 325035, China
2 School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou 325035, China |
|
|
|
Abstract Fibroblast growth factor 5 (FGF5) is a member of the fibroblast growth factor family (FGFs) and is expressed in mammalian hair follicles, nervous system, testis and other parts of the embryo and during embryonic development. The study found that FGF5 has a wide range of biological activities, such as an important regulator of hair growth, its genetic mutation will lead to abnormal hair growth; as a mitogen plays an important role in stem cell proliferation, angiogenesis and limb muscle development; It has important biological functions in hypertension and tumors. At present, the function and mechanism of action of FGF5 in various diseases need further study, but its biological effects in hair growth, stem cell proliferation and cardiovascular diseases have great significance and clinical application value. The research progress of FGF5 in recent years, systematically expounds the related mechanism of FGF5 in hair growth, stem cell proliferation and differentiation, cardiovascular disease and cancer, and provides further research on the role and development of FGF5 in disease treatment were summarized.
|
|
Received: 09 May 2019
Published: 18 April 2020
|
|
|
|
Corresponding Authors:
Xiao-kun LI
E-mail: profxiaokunli@163.com
|
|
|
| [1] |
Zhan X, Culpepper A, Reddy M , et al. Human oncogenes detected by a defined medium culture assay. Oncogene, 1987,1(4):369-376.
|
|
|
| [2] |
Zhan X, Bates B, Hu X G , et al. The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors. Molecular & Cellular Biology, 1988,8(8):3487-3495.
|
|
|
| [3] |
Itoh N, Ornitz D M . Evolution of the Fgf and Fgfr gene families. Trends in Genetics, 2004,20(11):563-569.
|
|
|
| [4] |
Haub O, Goldfarb D M . Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system. Proceedings of the National Academy of Sciences of the United States of America, 1990,87(20):8022-8026.
|
|
|
| [5] |
Hart A W, Baeza N, Apelqvist A , et al. Attenuation of FGF signalling in mouse β-cells leads to diabetes. Nature, 2000,408(6814):864-868.
|
|
|
| [6] |
Sundberg J P, Rourk M H, Boggess D , et al. Angora mouse mutation: altered hair cycle, follicular dystrophy, phenotypic maintenance of skin grafts, and changes in keratin expression. Veterinary Pathology, 1997,34(3):171-179.
|
|
|
| [7] |
Tian R, Yao C, Yang C , et al. Fibroblast growth factor-5 promotes spermatogonial stem cell proliferation via ERK and AKT activation. Stem Cell Research & Therapy, 2019,10 : 40.
|
|
|
| [8] |
Seo H R, Jeong H E, Joo H J , et al. Intrinsic FGF2 and FGF5 promotes angiogenesis of human aortic endothelial cells in 3D microfluidic angiogenesis system. Scientific Reports, 2016,6:28832.
|
|
|
| [9] |
Clase K L, Mitchell P J, Ward P J , et al. FGF5 stimulates expansion of connective tissue fibroblasts and inhibits skeletal muscle development in the limb. Developmental Dynamics, 2000,219(3):368-380.
|
|
|
| [10] |
Phuc K L T, Takuya A, Tomoyuki T , et al. Visualization of the epiblast and visceral endodermal cells using Fgf5-P2A-venus BAC transgenic mice and epiblast stem cells. PLoS One, 2016,11(7):e0159246.
|
|
|
| [11] |
Ren Y, Jiao X, Zhang L . Expression level of fibroblast growth factor 5 (FGF5) in the peripheral blood of primary hypertension and its clinical significance. Saudi Journal of Biological Sciences, 2018,25(3):469-473.
|
|
|
| [12] |
Kornmann M, Ishiwata T, Beger H G , et al. Fibroblast growth factor-5 stimulates mitogenic signaling and is overexpressed in human pancreatic cancer: evidence for autocrine and paracrine actions. Oncogene, 1997,15(12):1417-1424.
|
|
|
| [13] |
Higgins C A, Petukhova L, Harel S , et al. FGF5 is a crucial regulator of hair length in humans. Proceedings of the National Academy of Sciences, 2014,111(29):10648-10653.
|
|
|
| [14] |
Ornitz D M, Itoh N . Fibroblast growth factors. Genome Biology, 2001,2(3):30051-300512.
|
|
|
| [15] |
Bates B, Hardin J, Zhan X , et al. Biosynthesis of human fibroblast growth factor-5. Molecular and Cellular Biology, 1991,11(4):1840-1845.
|
|
|
| [16] |
Hattori Y, Yamasaki M, Itoh N . The rat FGF-5 mRNA variant generated by alternative splicing encodes a novel truncated form of FGF-5. Biochimica et Biophysica Acta, 1996,1306(1):31-33.
|
|
|
| [17] |
Housley D J, Venta P J . The long and the short of it: evidence that FGF5 is a major determinant of canine 'hair'-itability. Animal Genetics, 2010,37(4):309-315.
|
|
|
| [18] |
Zhang L, He S, Liu M , et al. Molecular cloning, characterization, and expression of sheep FGF5, gene. Gene, 2015,555(2):95-100.
|
|
|
| [19] |
Dickson C, Spencer-Dene B, Dillon C , et al. Tyrosine kinase signalling in breast cancer: Fibroblast growth factors and their receptors. Breast Cancer Research Bcr, 2000,2(3):191-196.
|
|
|
| [20] |
Ota Y, Saitoh Y, Suzuki S , et al. Fibroblast growth factor 5 inhibits hair growth by blocking dermal papilla cell activation. Biochemical and Biophysical Research Communications, 2002,290(1):169-176.
|
|
|
| [21] |
He X, Chao Y, Zhou G , et al. Fibroblast growth factor 5-short (FGF5s) inhibits the activity of FGF5 in primary and secondary hair follicle dermal papilla cells of cashmere goats. Gene, 2016,575(2):393-398.
|
|
|
| [22] |
Rosenquist T A, Martin G R . Fibroblast growth factor signalling in the hair growth cycle: Expression of the fibroblast growth factor receptor and ligand genes in the murine hair follicle. Developmental Dynamics, 1996,205(4):379-386.
|
|
|
| [23] |
Ornitz D M, Itoh N . The fibroblast growth factor signaling pathway. Wiley Interdiscip Rev Dev Biol, 2015,4(3):215-266.
|
|
|
| [24] |
Reed S A, Johnson S E . Expression of scleraxis and tenascin C in equine adipose and umbilical cord blood derived stem cells is dependent upon substrata and FGF supplementation. Cytotechnology, 2014,66(1):27-35.
|
|
|
| [25] |
Park G C, Song J S, Park H Y , et al. Role of fibroblast growth factor-5 on the proliferation of human tonsil-derived mesenchymal stem cells. Stem Cells and Development, 2016,25(15):1149-1160.
|
|
|
| [26] |
Peth?-Schramm A, Müller H J, Paus R . FGF5 and the murine hair cycle. Archives of Dermatological Research, 1996,288(5-6):264-266.
|
|
|
| [27] |
Müller-R?ver S ,Handjiski B,van der Veen C, et al. A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. Journal of Investigative Dermatology, 2001,117(1):3-15.
|
|
|
| [28] |
Stenn K S . Molecular insights into the hair follicle and its pathology: a review of recent developments. International Journal of Dermatology, 2010,42(1):40-43.
|
|
|
| [29] |
Kawano M, Komi-Kuramochi A, Asada M , et al. Comprehensive analysis of FGF and FGFR expression in skin: FGF18 is highly expressed in hair follicles and capable of inducing anagen from telogen stage hair follicles. Journal of Investigative Dermatology, 2005,124(5):877-885.
|
|
|
| [30] |
Dierks C, M?mke S, Philipp U , et al. Allelic heterogeneity of FGF5 mutations causes the long-hair phenotype in dogs. Animal Genetics, 2013,44(4):425-431.
|
|
|
| [31] |
Dr?gemüller C, Rüfenacht S, Wichert B , et al. Mutations within the FGF5, gene are associated with hair length in cats. Animal Genetics, 2010,38(3):218-221.
|
|
|
| [32] |
Legrand R, Tiret L, Abitbol M . Two recessive mutations in FGF5 are associated with the long-hair phenotype in donkeys. Genetics Selection Evolution, 2014,46(1):1-7.
|
|
|
| [33] |
Yoshizawa Y, Wada K, Shimoi G , et al. Erratum to: A 1-bp deletion in Fgf5 causes male-dominant long hair in the Syrian hamster. Mammalian Genome, 2016,27(1-2):98.
|
|
|
| [34] |
Hu R, Fan Z Y, Wang B Y , et al. Rapid communication: Generation of FGF5 knockout sheep via the CRISPR/Cas9 system12. Journal of Animal Science, 2017,95(5):2019-2024.
|
|
|
| [35] |
Dominic B, Masakuni Y, Masato N , et al. Promotion of anagen, increased hair density and reduction of hair fall in a clinical setting following identification of FGF5-inhibiting compounds via a novel 2-stage process. Clinical, Cosmetic and Investigational Dermatology, 2017,10:71-85.
|
|
|
| [36] |
Suzuki S, Kato T, Takimoto H , et al. Localization of rat FGF-5 protein in skin macrophage-like cells and FGF-5S protein in hair follicle: possible involvement of two Fgf-5 gene products in hair growth cycle regulation. Journal of Investigative Dermatology, 1998,111(6):963-972.
|
|
|
| [37] |
Suzuki S, Ota Y, Ozawa K , et al. Dual-mode regulation of hair growth cycle by two Fgf-5 gene products. Journal of Investigative Dermatology, 2000,114(3):456-463.
|
|
|
| [38] |
Ozawa K, Suzuki S, Asada M , et al. An Alternatively spliced fibroblast growth factor (FGF)-5 mRNA is abundant in brain and translates into a partial agonist/antagonist for FGF-5 neurotrophic activity. Journal of Biological Chemistry, 1998,273(44):29262-29271.
|
|
|
| [39] |
Saqie S, Naamnih W, Frei J , et al. Correlates of hospitalizations in internal medicine divisions among Israeli adults of different ethnic groups with hypertension, diabetes and cardiovascular diseases. PLoS One. 2019,14(4):e0215639.
|
|
|
| [40] |
Hanada K, Perrylalley D M, Ohnmacht G A , et al. Identification of fibroblast growth factor-5 as an overexpressed antigen in multiple human adenocarcinomas. Cancer Research, 2001,61(14):5511-5516.
|
|
|
| [41] |
Fang F, Chang R M, Yu L , et al. MicroRNA-188-5p suppresses tumor cell proliferation and metastasis by directly targeting FGF5 in hepatocellular carcinoma. Journal of Hepatology, 2015,63(4):874-885.
|
|
|
| [42] |
Meng Q H, Xu E ,Hildebrandt M A T, et al.Genetic variants in the fibroblast growth factor pathway as potential markers of ovarian cancer risk, therapeutic response, and clinical outcome. Clinical Chemistry, 2014,60(1):222-232.
|
|
|
| [43] |
Casimiro S, Inês Luis, Fernandes A , et al. Analysis of a bone metastasis gene expression signature in patients with bone metastasis from solid tumors. Clinical & Experimental Metastasis, 2012,29(2):155-164.
|
|
|
| [44] |
Metzner T, Bedeir A, Held G , et al. Fibroblast growth factor receptors as therapeutic targets in human melanoma: synergism with BRAF inhibition. Journal of Investigative Dermatology, 2011,131(10):2087-2095.
|
|
|
| [45] |
Zhou Y, Yu Q, Chu Y , et al. Downregulation of fibroblast growth factor 5 inhibits cell growth and invasion of human nonsmall-cell lung cancer cells. Journal of Cellular Biochemistry, 2018, 1-9.
|
|
|
| [46] |
Hughes R A, Sendtner M, Goldfarb M , et al. Evidence that fibroblast growth factor 5 is a major muscle-derived survival factor for cultured spinal motoneurons. Neuron, 1993,10(3):369-377.
|
|
|
| [47] |
Clase K L, Mitchell P J, Ward P J , et al. FGF5 stimulates expansion of connective tissue fibroblasts and inhibits skeletal muscle development in the limb. Developmental Dynamics, 2000,219(3):368-380.
|
|
|
| [48] |
Nobuyuki I, Yoshiaki N, Morichika K . Roles of FGFs as paracrine or endocrine signals in liver development, health, and disease. Frontiers in Cell and Developmental Biology, 2016,4:30.
|
|
|
| [49] |
Vigneron N, Stroobant V, Chapiro J , et al. An antigenicpeptide produced by peptide splicing in the proteasome. Science, 2004,304(5670):587-590.
|
|
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
