Research Progress of Non-coding RNA in Autophagy

doi:10.13523/j.cb.20191208

China Biotechnology

2019, Vol. 39

Issue (12): 56-63 DOI: 10.13523/j.cb.20191208

Research Progress of Non-coding RNA in Autophagy

SHEN Bing-lei(

),WANG Yu-xuan,HAN Shuo,LI Xi,YANG Zhuo-ni-na,ZOU Zi-wen,LIU Juan

College of Animal Science,Heilongjiang Bayi Agricultural University, Daqing 163319, China

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Abstract

Autophagy is a process in which cells degrade intracellular damaged components under stress conditions and involves the involvement of multiple signaling molecules.In the process of disease occurrence and development, autophagy can inhibit or delay the development of the disease, and can also make the disease worse. Therefore, it is of great significance to find the factors that regulate the autophagy at different stages to explore its effective target.Noncoding RNA (ncRNA) is a generic term for a class of RNA that is transcribed from the genome and does not travel to encode proteins. Over the years, more and more different ncRNAs have been discovered and play an important regulatory role in the physiological and pathological processes of animals.Studies have shown that ncRNA plays an important regulatory role in the process of autophagy.This article intends to review the regulation of ncRNA in the autophagy pathway from microRNAs (miRNAs), long noncoding RNAs (lncRNAs), circular RNAs (circRNAs), and to treat diseases such as cancer and Molecular markers provide theoretical guidance and new ideas.

Key words： Autophagy ncRNA microRNA lncRNA circRNA

Received: 16 April 2019 Published: 15 January 2020

ZTFLH:

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Corresponding Authors: Bing-lei SHEN E-mail: binglei514@163.com

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	Bing-lei SHEN
	Yu-xuan WANG
	Shuo HAN
	Xi LI
	Zhuo-ni-na YANG
	Zi-wen ZOU
	Juan LIU

Cite this article:

SHEN Bing-lei,WANG Yu-xuan,HAN Shuo,LI Xi,YANG Zhuo-ni-na,ZOU Zi-wen,LIU Juan. Research Progress of Non-coding RNA in Autophagy. China Biotechnology, 2019, 39(12): 56-63.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20191208 OR https://manu60.magtech.com.cn/biotech/Y2019/V39/I12/56

Fig.1 Schematic representation of the autophagy pathway and some core autophagy proteins

Table 1 Important miRNAs in the regulation of autophagy

Fig.2 Classification of lncRNA^[51]

Table 2 lncRNA involved in autophagy regulation


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