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| Advances in Autophagy on the Regulation of Neutrophil Function |
Xiao-yan YANG,Jing-dong MAO,Shu-sen LI,Xin-ying ZHANG,Li-yin DU( ) |
| College of Animal Science and Technology,Inner Mongolia University for Nationalities,Tongliao 028000,China |
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Abstract Autophagy is an evolutionarily highly conserved intracellular degradation system designed to maintain cellular homeostasis in response to cellular stress. In physiological states, the level of autophagy is usually low; however, it is significantly upregulated under oxidative stress, nutritional starvation, and various pathogens. Many studies in the past have shown that autophagy plays an important role in the regulation of various histiocytes and physiological functions. Early studies have found a link between autophagy and neutrophil death, a necessary process closely related to inflammation. Autophagy plays a crucial role in neutrophil-driven inflammation and defense against pathogens in human and mouse models. Autophagy is essential for neutrophil differentiation and major functions, including degranulation, reactive oxygen species production, and release of neutrophil extracellular trapping nets. The role of autophagy in neutrophils, from neutrophils to inflammatory responses and NETosis cell death in the bone marrow were focused.
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Received: 15 October 2018
Published: 12 July 2019
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Corresponding Authors:
Li-yin DU
E-mail: dly2000@aliyun.com
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