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Preparation of a Novel Surgical Sewing Thread with Control Release of Basic Fibroblast Growth Factor Through Electrospinning Technology |
Yi SONG1,**,Cui-yun ZHANG1,Yi LI1,Su-su ZHANG1,Shun PAN1,Yun-yun TAO1,Lu-yao XU1,Hua-cheng HE2,***(),Jiang WU1,***() |
1 School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China 2 College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China |
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Abstract Objective: Composite materials that surgical sewing thread with basic fibroblast growth factor slow release performance were prepared, and exploring its mechanical properties and in vitro release.Methods:By means of electrospinning technology, the efficiency of packaging was optimized by studying the ratio of material composition in composite materials. Furthermore, the influence of polycaprolactone-collagen composite structure (PCL-Col) on the controllable release of bFGF was studied, to prepare the surgical sewing thread with biological activity and drug sustained release performance. Finally, the microstructure of the sewing thread was observed, and the mechanical properties and the drug loading capacity were measured.Results:The results of scanning electron microscopy (SEM) showed that the surgical sewing thread had a complete linear structure. It is proved that the sewing thread has good mechanical properties by stretching and stretching cycle experiments. Finally, enzyme linked immune sorbent assay (enzyme linked immunosorbent assay,ELISA) proved that the surgical sewing thread had a certain of drug release properties.Conclusion:By using electrospinning device and optimizing spinning parameters, PCL-Col-bFGF surgical suture composite was successfully prepared. The sewing thread meets the mechanical properties requirement of suturing and has bFGF sustained release performance.
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Received: 23 June 2018
Published: 28 February 2019
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Corresponding Authors:
Yi SONG,Hua-cheng HE,Jiang WU
E-mail: hehc@wzu.ed.cn;woody870402@hotmail.com
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Cite this article:
Yi SONG,Cui-yun ZHANG,Yi LI,Su-su ZHANG,Shun PAN,Yun-yun TAO,Lu-yao XU,Hua-cheng HE,Jiang WU. Preparation of a Novel Surgical Sewing Thread with Control Release of Basic Fibroblast Growth Factor Through Electrospinning Technology. China Biotechnology, 2019, 39(1): 55-62.
URL:
https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20190107 OR https://manu60.magtech.com.cn/biotech/Y2019/V39/I1/55
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