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The Preparation Technology of Cell Drug |
WANG Dian-liang |
Tissue Engineering and Regenerative Medicine Laboratory, The General Hospital of The PLA Rocket Force, Beijing 100088, China |
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Abstract The quality of cell drug preparation is directly related to the curative efficacy of cell therapy. Due to the reason that the cells for cell therapy have biological effects, the preparation technology and application solution for cell drug are of diversity, complexity and particularity, unlike the traditional biological drugs that have a unified production standard. The preparation process of cell drugs mainly include donor screening, donor detection, collection, processing, separation and purification, storage and so on. The preparation technologies of several cell drugs including hematopoietic stem cell, mesenchymal stem cell, hepatic cell and dendritic cell are briefly introduced.
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Received: 04 February 2016
Published: 25 July 2016
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[1] Onizuka M,Matsushita H,Machida S,et al.Bacterial pneumonia-induced persistent remission of severe immune thrombocytopenia after allogeneic hematopoietic stem cell transplantation.Intern Med,2016,55(2):179-183.
[2] Sheppard D,Bredeson C,Huebsch L,et al.A plerixafor-based strategy allows adequate hematopoietic stem cell collection in poor mobilizers:results from the Canadian Special Access Program.Bone Marrow Transplant,201449(6):751-755.
[3] Veeraputhiran M,Jain T,Cronin S,et al.Successful hematopoietic stem cell collection in patients who fail initial plerixafor mobilization for autologous stem cell transplant.J Clin Apher,2014,29(6):293-298.
[4] Tassoni A,Gutteridge A,Barber A C,et al.Molecular mechanisms mediating retinal reactive gliosis following bone marrow mesenchymal stem cell transplantation.Stem Cells,2015,33(10):3006-3016.
[5] Pati S,Muthuraju S,Hadi R A,et al.Neurogenic plasticity of mesenchymal stem cell,an alluring cellular replacement for traumatic brain injury.Curr Stem Cell Res Ther,2016,11(2):149-157.
[6] Aras Y,Sabanci P A,Kabatas S,et al.The effects of adipose tissue-derived mesenchymal stem cell transplantation during the acute and subacute phases following spinal cord Injury.Turk Neurosurg,2016,26(1):127-139.
[7] Whiteley J,Bielecki R,Li M,et al.An expanded population of CD34+ cells from frozen banked umbilical cord blood demonstrate tissue repair mechanisms of mesenchymal stromal cells and circulating angiogenic cells in an ischemic hind limb model.Stem Cell Rev,2014,10(3):338-350.
[8] Badowski M,Muise A,Harris D T.Mixed effects of long-term frozen storage on cord tissue stem cells.Cytotherapy,2014,16(9):1313-1321.
[9] Rodrigues R M,Heymans A,De Boe V,et al.Toxicogenomics-based prediction of acetaminophen-induced liver injury using human hepatic cell systems.Toxicol Lett,2016,240(1):50-59.
[10] Bellwon P,Truisi G L,Bois F Y,et al.Kinetics and dynamics of cyclosporine A in three hepatic cell culture systems.Toxicol In Vitro,2015,30(1 Pt A):62-78.
[11] Wei X C,Yang D D,Han X R,et al.Bioactivity of umbilical cord blood dendritic cells and anti-leukemia effect.Int J Clin Exp Med,2015,8(10):19725-19730.
[12] Yan L,Wu M,Ba N,et al.Efficacy of dendritic cell-cytokine-induced killer immunotherapy plus intensity-modulated radiation therapy in treating elderly patients with esophageal carcinoma.Genet Mol Res,2015,14(1):898-905. |
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