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中国生物工程杂志

China Biotechnology
China Biotechnology
China Biotechnology  2014, Vol. 34 Issue (9): 113-121    DOI: 10.13523/j.cb.20140917
    
Recent Trends in Discovery and Protein Engineering of Biocatalysts
TANG Cun-duo1, SHI Hong-ling1, TANG Qing-hai1, JIAO Zhu-jing1, KAN Yun-chao1, WU Min-chen2, LI Jian-fang3
1. China-UK-NYNU-RRes Joint Laboratory, Nanyang Normal University, Nanyang 473061, China;
2. Wuxi Medical School, Jiangnan University, Wuxi 214122, China;
3. School of Food Science and Technology, Jiangnan University, Wuxi 214122, China
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Abstract  

Biocatalysis is the process of applying enzymes or biological organisms in useful chemical conversion. In the context of concerns about the environmental aspects of the traditional chemical catalysis, biocatalysis provides an attractive alternative. In the past few decades, with a great progress on the study of biocatalysts, there will relevantly be a development wave on biocatalysis. So, the discovery and protein engineering of biocatalysts are becoming a hotspot in current researches. The emergence of the metagenomic library technology overcomes the barriers that many microorganism can not be cultured, hence more and more potential biocatalysts can be gained from natural resources. Owing to the development of the molecular modification technologies based on the rational design, rapid and efficient protein engineering of potential biocatalysts can be done to meet the need of industrial production. With the progress of the discovery and protein engineering method of biocatalysts, more and more excellent biocatalysts have been widely used, and biocatalysis have further application in the industrial production. The latest progress on the discovery and protein engineering of biocatalysts based on the research work were summarized to provide the theoretical foundation for getting more excellent biocatalysts which can be applied on industrial scale.

Key words： Biocatalysts      Metagenomic library      Genome mining      Molecular modification      in silico design     
Received: 03 July 2014      Published: 25 September 2014
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Cite this article:

TANG Cun-duo, SHI Hong-ling, TANG Qing-hai, JIAO Zhu-jing, KAN Yun-chao, WU Min-chen, LI Jian-fang. Recent Trends in Discovery and Protein Engineering of Biocatalysts. China Biotechnology, 2014, 34(9): 113-121.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20140917     OR     https://manu60.magtech.com.cn/biotech/Y2014/V34/I9/113


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