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中国生物工程杂志

China Biotechnology
China Biotechnology  2011, Vol. 31 Issue (9): 96-102    DOI:
    
Biological Function of β-catenin and Its Progress in Hepatocellular Carcinoma Research
HAN Tao, DING Jin, WANG Hong-yang
International Cooperation Laboratory on Signal Transduction, Eastern Hepato-biliary Surgery Institute, Second Military Medical University, Shanghai 200438, China
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Abstract  

β-catenin, encoded by CTNNB1 gene on chromosome 3p21—22, is a multi-functional protein which mediates cell adhesion and signal transduction. It plays an important role in embryonic development and tumorigenesis by participating in regulation of cell proliferation and differentiation. In recent years, an increasing number of studies have revealed that inappropriate activation of the canonical Wnt pathway plays an important role in the pathophysiological process of hepatocellular carcinoma (HCC). As a pivotal molecule in Wnt signal transduction pathway, the abnormal expression of β-catenin is closely associated with the development of hepatocellular carcinoma. The latest progress of the role of β-catenin in hepatocellular carcinoma is reviewed.



Key wordsβ-catenin      Hepatocellular carcinoma      Signal transduction     
Received: 31 March 2011      Published: 25 September 2011
ZTFLH:  Q7  
Cite this article:

HAN Tao, DING Jin, WANG Hong-yang. Biological Function of β-catenin and Its Progress in Hepatocellular Carcinoma Research. China Biotechnology, 2011, 31(9): 96-102.

URL:

https://manu60.magtech.com.cn/biotech/     OR     https://manu60.magtech.com.cn/biotech/Y2011/V31/I9/96


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