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中国生物工程杂志

China Biotechnology
China Biotechnology  2015, Vol. 35 Issue (4): 86-91    DOI: 10.13523/j.cb.20150413
    
Aptamer Conjugated Nanomaterials for Targeted Cancer Therapeutics
HE Min-yu, RAN Hai-tao
Institute of Ultrasound Imaging & Department of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University; Chongqing Key Laboratory of Ultrasound Molecular Imaging, Chongqing 400010, China
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Abstract  

Aptamers is a kind of oligonucleotides which are isolated through a process termed systematic evolution of ligands by exponential enrichment. Because of its peculiar molecular recognition ability and the specific structure, aptamer is one of the most prospectly biological molecules. An overview of recent developments in aptamer nanomaterial hybrid was presented.



Key wordsAptamer      Tumor targeted     
Received: 14 November 2014      Published: 25 April 2015
ZTFLH:  Q819  
Cite this article:

HE Min-yu, RAN Hai-tao. Aptamer Conjugated Nanomaterials for Targeted Cancer Therapeutics. China Biotechnology, 2015, 35(4): 86-91.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20150413     OR     https://manu60.magtech.com.cn/biotech/Y2015/V35/I4/86


[1] Ellington A D, Szostak J W. In vitro selection of RNA molecules that bind specific ligands. Nature, 1990, 346(6287):818-822.

[2] Tuerk C, Goid L. Systematic evoiution of ligands by exponential enrichment:RNA ligands to bacteriophage T4 DNA polymerase. Science, 1990,249(4968):505-510.

[3] Syed M A, Pervaiz S. Advances in aptamers. Oligonucleotides, 2010,20(5):215-224.

[4] Goringer H U, Adler A, Forster N, et al. Post-SELEX chemical optimization of a trypanosome-specific RNA aptamer. Comb Chem High Throughput Screen, 2008,11(8):16-23.

[5] Song K M, Lee S, Ban C. Aptamers and their biological applications. Sensors, 2012,12(1):612-631.

[6] Lee J H, Yigit M V, Mazumdar D, et al. Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates. Adv Drug Deliv Rev, 2010,62(6):592-605.

[7] Yang L, Zhang X, Ye M, et al. Aptamer-conjugated nanomaterials and their applications. Adv Drug Deliv Rev, 2011,63(14-15):1361-1370.

[8] Li X,Zhao Q, Qiu L. Smart ligand: Aptamer-mediated targeted delivery of chemotherapeutic drugs and siRNA for cancer therapy. J Controll Release, 2013,171(2):152-162.

[9] Ashrafuzzaman M. Aptamers as both drugs and drug-carriers. Biomed Res Int, 2014,(2014):697923-697944.

[10] 杨传旭,葛志强. 以适体作为药物"靶向载体"的研究进展. 中国医药生物技术,2010, 5(4):297-299. Yang C X, Ge Z Q. Progress on aptamer as guide for targeting drug delivery. Chin Med Biotechnol, 2010, 5(4):297-299.

[11] 朱尧, 吕颖慧, 杨会勇,等. 抗病毒适体药物的研究进展. 药学学报,2013, 48 (4): 447-456. Zhu Y, Lv Y H, Yang H Y,et al. Recent progress of the aptamer-based antiviral drugs. Acta Pharmaceutica Sinica, 2013, 48 (4): 447-456.

[12] 王国庆,陈兆鹏,陈令新,等. 基于核酸适配体和纳米粒子的光学探针. 化学进展,2010,22(2-3):489-499. Wang G Q, Chen Z P, Chen L X, et al. Aptamer-nanoparticle-based optical probes. Progress in Chemistry, 2010,22(2-3):489-499.

[13] Lee J H, Jucker F, Pardi A. Imino proton exchange rates imply an induced-fit binding mechanism for the VEGF165-targeting aptamer,Macugen. FEBS Letters, 2008,582(13):1835-1839.

[14] Bates P J, Laber D A, Miller D M, et al. Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer. Exp Mol Pathol, 2009,86(3):151-164.

[15] Reyes-Reyes E M, Teng Y, Bates P J. A new paradigm for aptamer therapeutic AS1411 action:uptake by macropinocytosis and its stimulation by a nucleolin-dependent mechanism. Cancer Res, 2010,70(21):8617-8629.

[16] Keefe A D, Pai S, Ellington A. Aptamers as therapeutics. Nat Rev Drug Discov, 2010, 9(7):537-550.

[17] Kruspe S, Mittelberger F, Szameit K, et al. Aptamers as drug delivery vehicles. Chem Med Chem, 2014,9(9):1998-2011.

[18] Huang Y F, Sefah K, Bamrungsa P S, et al. Selective photothermal therapy for mixed cancer cells using aptamer-conjugated nanorods. Langmuir, 2008,24(20):11860-11865.

[19] Luo Y L, Shiao Y S, Huang Y F. Release of photoactivatable drugs from plasmonicnanoparticles for targeted cancer therapy. ACS Nano, 2011,5(10):7796-7804.

[20] Du Y Q, Yang X X, Li W L, et al. A cancer-targeted drug delivery system developed with gold nanoparticle mediated DNA-doxorubicin conjugates. RSC Advances, 2014, 4(66): 34830-30835.

[21] Zhu C L, Song X Y, Zhou W H, et al. An efficient cell-targeting and intracellular controlled-release drug delivery system based on MSN-PEM-aptamer conjugates. J Mater Chem, 2009,19(41):7765-7770.

[22] Yang X J, Liu X, Liu Z, et al. Near-infrared light-triggered,targeted drug delivery to cancer cells by aptamer gated nanovehicles. Adv Mater, 2012,24(21):2890-2895.

[23] Yu M K, Kim D, Lee I H, et al. Image-guided prostate cancer therapy using aptamer-functionalized thermally cross-linked superparamagnetic iron oxide nanoparticles. Small, 2011,7(15):2241-2249.

[24] Meng L, Zhang X, Lu Q, et al. Single walled carbon nanotubes as drug delivery vehicles: targeting doxorubicin to tumors. Biomaterials, 2012,33(6):1689-1698.

[25] Zhang H J, Chen C Q, Hou L, et al. Targeting and hyperthermia of doxourubicin by the delivery of single-walled carbon nanotubes to EC-109 cells. Journal of Drug Targeting, 2013, 21(3): 312-319.

[26] Cao Z, Tong R, Mishra A, et al.Reversible cell-specific drug delivery with aptamer-functionalized liposomes. Angew Chem Int Ed, 2009,48(35):6494-6498.

[27] Kang H, O'Donoghue M B, Liu H, et al. A liposome-based nanostructure for aptamer directed delivery. Chem Commun, 2010,46(2):249-251.

[28] Ara M N, Matsuda T, Hyodo M, et al. Construction of an aptamer modified liposomal system targeted to tumor endothelial cells. Biol Pharm Bull, 2014,37(11):1742-1749.

[29] Farokhzad O C, Cheng J, Teply B A, et al. Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. Proc Natl Acad Sci U S A, 2006,103(16):6315-6320.

[30] Dhar S, Gu F X, Langer R, et al. Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt (IV) prodrug-PlGA-PEG nanoparticles. Proc Natl Acad Sci USA, 2008,105(45):17356-17361.

[31] Athulya A, Prashanti J, Remya N, et al. AS1411 aptamer tagged PLGA-lecithin-PEG nanoparticles for tumor cell targeting and drug delivery. Biotechnology and Bioengineering, 2012,109 (11): 2920-2931.

[32] Li L, Xiang D, Shigdar S, et al. Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells. Int J Nanomedicine, 2014,21(9):1083-1096.

[33] Liu J, Liu H, Kang H,et al. Aptamer-incorporated hydrogels for visual detection,controlled drug release,and targeted cancertherapy. Anal Bioanal Chem, 2012,402(1):187-194.

[34] Bagalkot V, Zhang L, Levy-Nissenbaum E,et al. Quantum dot-aptamer conjugates for synchronous cancer imaging, therapy, and sensing of drug delivery based on bi-fluorescence resonance energy transfer. Nano Lett, 2007,7(10):3065-3070.

[35] Bagalkot V, Farokhzad O C, Langer R,et al. An aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform. Angew Chem Int Ed, 2006, 45(48):8149-8152.

[36] Xie L L, Tong W J, Yu D H, et al. Bovine serum albumin nanoparticles modified with multilayers and aptamers for pH-responsive and targeted anti-cancer drug delivery. J Mater Chem, 2012,22(13): 6053-6060.

[37] Mascini M. Aptamers and their applications.Anal Bioanal Chem,2008,390(4):987-988.

[38] Doudna J A,Cech T R,Sullenger B A.Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor.Proc Natl Acad Sci USA,1995,92(6):2355-2359.

[39] Eaton B E,Gold L,Zichi D A.Let's get specific:the relation-ship between specificity and affinity.Chem & Biol,1995,2(10):633-638.

[40] Long S B,Long M B,White R R,et al.Crystal structure of an RNA aptamer bound to thrombin. RNA,2008,14:2504-2512.

[41] Becker RC,Rusconi C,Sullenger B.Nucleic acid aptamers in therapeutic anticoagulation. Technology, development and clinical application.Thromb Haemost,2005,93(6):1010-1201.

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