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Progress in neural Differentiation of Umbilical Cord Blood - derived Stem Cells |
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Abstract Several studies from different laboratories have recently reported that stem cells from human umbilical cord blood can be induced to proliferate and differentiate into glia and neurons in vitro and improve functional recovery after central nervous system injury in vivo. The existence of stem/progenitor cells with previously unappreciated proliferation and differentiation potential in umbilical cord blood raise the possibility that cord blood may provide an efficient source of cells differentiating into the neural lineage, with a potential to be employed in the therapy of human CNS diseases. This article reviews achievement in this field and focuses on the mechanisms and modulation of induction of differentiation and in vitro and in vivo studies.
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Received: 24 October 2005
Published: 25 June 2006
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