Please wait a minute...

中国生物工程杂志

China Biotechnology
China Biotechnology  2010, Vol. 30 Issue (11): 75-78    DOI:
    
P14ARF Signaling Pathway
PEI Hai-long1,2, ZHOU Guang-ming1
1. Insititute of Modern Physics,Chinese Academy of Sciences,Lanzhou 730000,China;
2. Graduate University of Chinese Academy of Sciences,Beijing 100049,China
Download: HTML   PDF(506KB) HTML
Export: BibTeX | EndNote (RIS)      

Abstract  

p14ARF is a newly discovered tumor suppressor gene which functions in cell cycle regulation. P14ARF mainly locates in nucleoli with some others positioned on the nuclearplasma. p14ARF also inactivated in some human tumor high frequencily. Now more and more attention focus on the mechanism of p14ARF abnormalities leading to tumor as well as applying P14ARF as a target for cancer gene therapy.The signaling pathway for P14ARF was reviewed.



Key wordsP14ARF      Tumor suppressor gene      Signaling pathway      Ionizing radiation     
Received: 15 July 2010      Published: 19 November 2010
ZTFLH:  Q691  
Corresponding Authors: Pei Hai-Long     E-mail: zhougm@impcas.ac.cn
Cite this article:

PEI Hai-long, ZHOU Guang-ming. P14ARF Signaling Pathway. China Biotechnology, 2010, 30(11): 75-78.

URL:

https://manu60.magtech.com.cn/biotech/     OR     https://manu60.magtech.com.cn/biotech/Y2010/V30/I11/75

[1] 左超海.p14ARF与人类肿瘤.海南医学院学报,2005,11(1):78-80. Zuo H C.Journal of Hainan Medical College,2005,11(1):78-80.
[2] Ouelle D E, Zindy F, Ashmun R A, et al. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell, 1995, 83(6): 993-1000.
[3] Sherr C J,Weber J D.The ARF/p53 pathway.Curr Opin Genet Deve,2000,10(1):94-99.
[4] Jenny C G,Peng M G,Fiona C,et al. Apoptosis gene profiling reveals spatio-temporal regulated expression of the p53/Mdm2 pathway during lens development.Ex PEye Res,2009,88(6):1137-1151.
[5] Llanos S, Clark P A, Rowe J,et al. Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus. Nat Cell Biol,2001,3:445-452.
[6] Korgaonkar C, Zhao L, Modestou M,et al. ARF function does not require p53 stabilization or Mdm2 relocalization. Mol Cell Biol,2002,22:196-206.
[7] Robertson K D,Jones P A.The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.Mol Cel Biol,1998,18(11):6457-6473.
[8] Yarbrough W G,Bessho M,Zanation A,et al.Human tumor suppressor ARF impedes S-phase progression independent of p53.Cancer Res,2002,62(4):1171-1177.
[9] Bhishek D,Alo N,Nissim H,et a1.Myc-ARF(alternate reading frame)interaction inhibits the functions of Myc.J Biol Chem,2004,279(35):36698-36707.
[10] Yozo N,Takehiko K,Kenichi K,et a1.ARF tumot suppressor induces mitochondria-dependent apopotosis by modulation of mitochondrial Bcl-2 family proteins.J Blol Chem,2003,278(30):27888-27895.
[11] Suzuki H,Kurita M,Mizumoto K,et a1.The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression.Biochem Bio Phys Res Commun,2005,326(1):242-248.
[12] Mason S I,Longhran O,La Thangue N B.P14(ARF) regulate E2F activity.Oncogene,2002,21(27):4220-4230.
[13] Eymin B,Karayan L,Seite P,et a1.Human ARF binds E2F1 and inhibits its transcriptional activity.Oncogene,2001,20(9):1033-1041.
[14] Bates S,Phillips A C,Clark P A,et al.pl4ARF links the tumour suppressors RB and p53.Nature,1998,395(6698):124-125.
[15] 田凯华,赵慧茹,赵凡,等。非小细胞肺癌中p14ARF、p16INK4a和p53蛋白表达及相互关系的研究.中华肿瘤临床,2004,31(7):376-379. Tian K H, Zhao H R, Zhao F,et al.Chinese Journal of Clinical Oncology, 2004,31(7):376-379.
[16] 李鹏,高德伟,周平坤.辐射诱发支气管癌变细胞中p14ARF、p16INK4a及BUB3基因甲基化分析.中国肺癌杂志,2006,9(3):241-244. Li P, Gao D W, Zhou P K, et al.Chinese Journal of Lung Cancer,2006,9(3):241-244.
[17] Silva J,Silva J M,Dominguez G, et al.Concomitant expression of p16INK4a and p14ARF in primary breast cancer and analysis of inactivation mechanisms.Pathol,2003,199(3):289-297.
[18] 高栋,段建敏,米军.膀胱移行细胞癌p16、p15、p14基因5'CpG岛甲基化检测.兰州大学学报(医学版),2006,32(3):18-20. Gao D, Duan J M, Mi J.Journal of Lanzhou University(Medical Sciences), 2006,32(3):18-20.
[19] 庞瑾昱,杨宣琴,李素红,等.胃癌中p14、p15、p16基因微卫星不稳定性的研究.肿瘤研究与临床,2007,19(8):512-515. Pang J Y, Yang X Q, Li S H, et al.Cancer Research and Clinic, 2007,19(8):512-515.
[20] Teis D,Taub N,Kurzbauer R,et al.p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissuehomeostasis. J Biol Chem,2006,175(6):861-868.
[21] Kurzbauer R,Teis T,Mariana E G,et al.Crystal structure of the p14/MP1 scaffolding complex: How a twin couple attaches mitogenactivated protein kinase signaling to late endosomes.PNAS,2004,101(30):10984-10989.
[22] Galabova K G, Matzen K D, et al. i ERK nsights from B-Raf and Raf-1 conditional knockouts. Cell Cycle,2006(5):1514-1518.
[23] Pullikuth A,McKinnon E,Schaeffer H J,et al. The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals. Mol. Cell. Biol,2005,25:5119-5133.
[24] Qi Y, Gregory M A, Li Z, et al. p19ARF directly and differentially controls the functions of c-Myc independently of p53. Nature,2004, 431:712-717.
[25] Oster S K, Ho C S, Soucie E L,et al. The myc oncogene: Marvelously complex. Adv Cancer Res,2002, 84:81-154.
[26] Datta A, Nag A, Pan W,et al. Myc-ARF (alternate reading frame) interaction inhibits the functions of Myc. J Biol Chem,2004, 279:36698-366707.
[27] Gregory M A, Qi Y, Han S R.The ARF tumor suppressor keeping Myc on a Leash. Cell Cycle,2005,4(2):249-252.
[28] Cui Q H,Ma Y,Jaramillo M,et al。A ma Pof human cancer signaling.Molecular Systems Biology,2007,3(152):1-13.
[29] 刘峰.α粒子诱发癌变细胞中p14和p16基因甲基化及表达变化.北京:中国人民解放军军事医学科学院,2004. Liu F. α-particle-induced Cancer Cell p14 and p16 Gene Methylation and Expression Change.Beijing:Academy of Military Medical Sciences,2004.
[30] Sonia M D,Edouard I A,William K D,et al.ATM complexes with HDM2 and promotes its rapid phosphorylation in a p53-independent manner in normal and tumor human cells exposed to ionizing radiation.Oncogene,2000,19:6185-6193.

[1] DAI Li-ting, WU Zhong-nan, HUANG Xiang, YANG Jie, ZENG Hui-lan, WANG Guo-cai, JIANG Jian-wei. Molecular Mechanism of Inducing GLC-82 Cells Apoptosis by Ethanol Extract from Wedelia prostrate(Hook.et Arn.) Hemsl[J]. China Biotechnology, 2017, 37(8): 1-7.
[2] LI Ai-fang, GU Yue, LI Xue-ru, SUN Hui, ZHA He, XIE Jia-qing, ZHAO Jia-li, ZHOU Lan. Effects of S100A6 on Proliferation and Migration of Human Cervical Cancer Cells and Its Mechanism[J]. China Biotechnology, 2017, 37(2): 8-14.
[3] LI Hong-chang, YUAN Lin, ZHANG Ling-qiang . Construction of Transgenic Mice and Phenotypic Analysis of Tumor Suppressor PTEN[J]. China Biotechnology, 2015, 35(8): 1-8.
[4] LIU Jing, LUO Chao-chao, HUANG Jian-guo, WU Di, GAO Xue-jun, LIU Yu-fen. 14-3-3γ Regulates the Physiological Function of Dairy Cow Mammary Gland Epithelial Cells Through mTOR Signaling Pathway[J]. China Biotechnology, 2015, 35(6): 32-39.
[5] ZHANG Chao, XIANG Li-na, CHEN De-pei, LÜ Xin-xin, ZHAO Yi-tong, WANG Lu-yao, XIAO Jian, ZHANG Hong-yu. The Development of the Study on bFGF Promote the Nerve Injury Repair[J]. China Biotechnology, 2015, 35(6): 75-79.
[6] HU Yan-zhen, WEI Jun-ying, LUO Guang-ming. Research on Glutathione-related Signaling Pathway in Liver Diseases[J]. China Biotechnology, 2015, 35(10): 72-77.
[7] SHI Juan, YANG Jia-li, MA Ling-jie, BAO Shao-wen, MA Yan, CHENG Long, MA Chun-yan, LI Yong, LIU Xiao-ming. The Role of Canonical Wnt Signaling Pathway in the Lung Epithelial Cells against Mycobacteria Infection[J]. China Biotechnology, 2013, 33(12): 9-14.
[8] XIE Jia-ying, XU Wen-chun, XU Dao-jing, ZHANG Xiao-yan, TANG Min. Role of Notch Signaling Pathway in Bone Morphogenetic Protein 9-induced Ostegenic Differentiation of Marrow-derived Mesenchymal Stem Cells and Its Mechanism[J]. China Biotechnology, 2012, 32(11): 14-22.
[9] XIE Jia-ying, XU Wen-chun, XU Dao-jing, ZHANG Xiao-yan, TANG Min. Role of Notch Signaling Pathway in Bone Morphogenetic Protein 9-induced Ostegenic Differentiation of Marrow-derived Mesenchymal Stem Cells and Its Mechanism[J]. China Biotechnology, 2012, 32(11): 14-22.
[10] LI Yu-ye, LI Xing-xing, SUN Shuang-shuang, ZOU Zheng-yu, ZHANG Yun-yuan, DUAN Liang, YE Li-wei, WU Rui, YANG Xia, HE Tong-chuan, ZHOU Lan. Effects and Possible Mechanism of Protein S100A6 on β-catenin[J]. China Biotechnology, 2011, 31(11): 18-23.