Rex-1 Regulate The Transcriptional Activity Of Oct4 Through Direct Protein Interaction

China Biotechnology

2009, Vol. 29

Issue (09): 0-0 DOI:

Rex-1 Regulate The Transcriptional Activity Of Oct4 Through Direct Protein Interaction

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Abstract Rex-1 and Oct4 are transcription factors which are specifically expressed in pluripotent cells. However, the molecular mechanisms of Rex-1 and Oct4 regulating the pluripotency and differentiation of embryonic stem cells (ES cells) are not very clear. The interaction between Rex-1 and Oct4 is studied here. Rex-1 and Oct4 co-localize in the nucleus and have direct protein interaction. Rex-1 inhibits the transcriptional activity of Oct4 through this interaction.

Key words： ES cell Transcription factor Rex-1 Oct4

Received: 28 April 2009 Published: 10 May 2010

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	GUO Yuan-Qian
	RAO Yan-Hua
	DIAO Yuan
	FEI Duan-Qing

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. Rex-1 Regulate The Transcriptional Activity Of Oct4 Through Direct Protein Interaction. China Biotechnology, 2009, 29(09): 0-0.

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https://manu60.magtech.com.cn/biotech/ OR https://manu60.magtech.com.cn/biotech/Y2009/V29/I09/0

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