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| Express and regulation of Animal anti-hypoxia stress-related genes |
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Abstract Maintenance of oxygen homeostasis is important to cellular and systemic function. Under hypoxia condition, a powerful defense of organism is triggered by the hypoxia signal to protect tissue and organs. In the process of defense, some genes are up-regulated, such as Hypoxia inducible factor-1 (HIF-1)、vascular endothelial growth factor (VEGF)、erythropoietin (EPO) and nuclear factor-κB (NF-κB). HIF-1 is a anti-hypoxia stress-related genes and encodes a transcription factor, The regulation of HIF-1 activity is related to the oxygen concentration. VEGF is a target gene of HIF-1, which is one of the most critical antigenic factor identified to date. EPO can promote the differentiation and proliferation of red blood cells under hypoxia conditions. NF-κB can inhibit cell apoptosis which is induced by hypoxia. Obviously, these genes play important roles in protecting organism from hypoxia stress. In this review, the function, expression pattern and regulation mechanism of HIF-1, VEGF, NF-κB and EPO in hypoxia are summarized.
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Received: 01 June 2010
Published: 19 October 2010
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