Abstract Abstract The combination of biology and micro/nano fabrication technology is becoming a new trend, DNA molecules have many characteristics, such as good thermal stability, linear geometry structure and mechanical rigidity, which can be used as ideal templates for nanowire fabrication. By utilizing metallization technology, DNA can make up conductive metal nanowires and nanoclusters, which provides a possibility of constructing nano-devices by metallized DNA molecules. In this article, firstly, we introduce DNA metallization principles. Secondly, we discuss several novel DNA metallization processes, including whole DNA metallization, selective DNA metallization, ionic surface masking decreasing nonspecific DNA metallization and evaporation DNA metallization. Finally, by self-assembly and self-recognition techniques, metallized DNA can be used to build up electronic circuits and used as the metal deposition templates to construct bio-nano devices.
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