The process of mesenchymal stem cells and their potential as cardiac therapeutics

China Biotechnology

2007, Vol. 27

Issue (6): 107-110 DOI:

The process of mesenchymal stem cells and their potential as cardiac therapeutics

Download:

HTML

PDF(353KB) HTML
Export: BibTeX | EndNote (RIS)

Abstract

Bone marrow mesenchymal stem cells (MSCs), multipotent stem cells, can replicate as undifferentiated cells and have the potential to differentiate into different lineages of mesenchymal tissues, including bone, cartilage，endothelial, neural, smooth muscle, skeletal myoblasts, and cardiac myocyte cells. The ischemia-induced death of cardiomyocytes results in scar formation and reduced contractility of the ventricle. Several preclinical and clinical studies have supported the notion that MSCs therapy may be used for cardiac regeneration.When transplanted into the infracted heart, MSCs prevent deleterious remodeling and improve recovery, but the mechanism is not clear. In this work,we review evidence and new prospects that support the use of MSCs in cardiomyoplasty.

Key words： mesenchymal stem cells cell transplant cellular fusion paracrine effects.

Received: 19 January 2007 Published: 25 June 2007

	Service
	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

. The process of mesenchymal stem cells and their potential as cardiac therapeutics. China Biotechnology, 2007, 27(6): 107-110.

URL:

https://manu60.magtech.com.cn/biotech/ OR https://manu60.magtech.com.cn/biotech/Y2007/V27/I6/107

[1]	WANG Yu-xuan,CHEN Ting,ZHANG Yong-liang. Research Progress on the Biological Function of MiR-148[J]. China Biotechnology, 2021, 41(7): 74-80.

[2]	LI Kai-xiu,SI Wei. Progress in the Treatment of Inflammatory Bowel Diseases by Exosomes Derived from Mesenchymal Stem Cells[J]. China Biotechnology, 2021, 41(7): 66-73.

[3]	ZHAO Jiu-mei,WANG Zhe,LI Xue-ying. Role of Signal Pathways and Related Factors Regulating Cartilage Formation in Bone Differentiation of Bone Marrow Mesenchymal Stem Cells[J]. China Biotechnology, 2021, 41(10): 62-72.

[4]	CHEN Fei,WANG Xiao-bing,XU Zeng-hui,QIAN Qi-jun. Molecular Mechanism and Clinical Research Progress of Mesenchymal Stem Cells in the Treatment of Diabetes Mellitus[J]. China Biotechnology, 2020, 40(7): 59-69.

[5]	YUAN Ya-kun,LIU Guang-yang,LIU Yong-jun,XIE Ya-fang,WU Hao. Comparison of Research and Clinical Transformation on Mesenchymal Stem Cells between China and the US[J]. China Biotechnology, 2020, 40(4): 97-107.

[6]	CHEN Li-jun,QU Jing-jing,XIANG Charlie. Therapeutic Potentials, Clinical Studies, and Application Prospects of Mesenchymal Stem Cells in 2019 Novel Coronavirus (COVID-19)[J]. China Biotechnology, 2020, 40(11): 43-55.

[7]	ZHU Yongzhao,TAO Jin,REN Meng-meng,XIONG Ran,HE Ya-qin,ZHOU Yu,LU Zhen-hui,DU Yong,YANG Zhi-hong. Autophagy Protects Against Apoptosis of Human Placental Mesenchymal Stem Cells of Fetal Origin Induced by Tumor Necrosis Fator-α[J]. China Biotechnology, 2019, 39(9): 62-67.

[8]	Wen-wen SHI,Lei ZHANG. Current Research of Micro Mechanical Environmental Effects on Mesenchymal Stem Cells’ Differentiation[J]. China Biotechnology, 2018, 38(8): 76-83.

[9]	Yan ZHENG,Huan YAO,Ke YANG. SFRP5 Inhibites Osteogenic Differentiation of Human Umbilical Cord-derived Mesenchymal Stem Cells Induced by BMP9[J]. China Biotechnology, 2018, 38(7): 7-13.

[10]	YUAN Ya-hong, ZHAO Shan-shan, WANG Xiao-li, TENG Zhi-ping, LI Dong-sheng, ZENG Yi. HIV-1 Tat Protein Inhibits the Hematopoiesis Support Function of Bone Marrow Mesenchymal Stem Cells[J]. China Biotechnology, 2017, 37(6): 1-8.

[11]	CAO Jun-jie, LI Ai-fang, WEI Ya-lin, LIAN Jing, TANG Min. Role of Notch Signaling Pathway in Bone Morphogenetic Protein 4-induced Osteogenic Differentiation of Marrow-derived Mesenchymal Stem Cells and Its Mechanism[J]. China Biotechnology, 2017, 37(4): 48-55.

[12]	CHEN Gang, WU Jun, ZHU He, YU Tian-fei. Progress of Stem Cell Therapy in Spinal Cord Injury[J]. China Biotechnology, 2017, 37(2): 88-92.

[13]	ZHAO Zheng-de, CHEN Zhen-yin, ZHANG Hui-nan, GONG Jian-ping, XU Shao-dan, LUO Zhong-li. Effects of Self-assembling Peptide Hydrogel Scaffolds for Three-dimensional Culture on Biological Behavior and Capability of Myocardium Differentiation in Bone Marrow Mesenchymal Stem Cells[J]. China Biotechnology, 2017, 37(11): 45-51.

[14]	MAO Kai-yun, FAN Yue-lei, WANG Yue, LU Jiao, CHEN Da-ming. Development Status and Trend Analysis of Mesenchymal Stem Cells Therapeutic Products[J]. China Biotechnology, 2017, 37(10): 126-135.

[15]	ZHANG Qing-fang, LIU Ru-ming, XIAO Jian-hui. Application of Hyaluronic Acid on the Cartilage Differentiation of Mesenchymal Stem Cells[J]. China Biotechnology, 2016, 36(6): 92-99.

Viewed

Full text

Abstract

Cited

Shared

Discussed