Abstract As an application of peptides and protein drug- delivery system, liposome is a kind of promising, broadly applicable drug-delivery system. It can control the drug releasing、deduce the drug toxicity、have the target proerty and so on. In this article , the mainly development including the methods of preparation, new liposomes, administeration of peptides and protein liposomes, was reviewed, according to the references of the development of peptides and protein liposomes in recent 10 years, Furthermore, the updated progresses of liposome of peptides and protein drugs were described, in order to provide some references to the research on liposome in biological area. Some problems in this drug- delivery system were also put forward. Although liposome has made considerable progress and development in the biological area, there are many technological tough problems have not been tackled. The further research on peptides and protein liposomes is also needed.
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