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Abstract CD127 is the interleukin-7 receptor α (IL-7Rα), it regulates the specific respond of T lymphocytes to IL-7. CD127 plays an indispensable role in the development of thymocytes into T lymphocytes, the survival and homeostatic proliferation of memory T cells. There are only two phases of the life period of T cells that do not express CD127: immature CD4+8+double positive (DP) thymocytes and activated T cells. Recently, CD127 was found that it play an important role as the specific marker of memory T cells and regulator T cells. The role and mechanism of CD127 in the life period of T cells were discussed herein
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Received: 22 January 2007
Published: 25 May 2007
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