| 研究报告 |
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| Metallothionein induced by Selenium and the protection on mice liver injury of selenium-metallothionein |
| GANG Zuo |
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Abstract Using Proteinchip and RT-PCR to verify the induction of metallothionein by selenium. Results showed there was definite effect of metallothionein induced by selenium, and indicated the protection of mice liver injury by selenium , the biomarker of liver injury had also been found. The effect induced by organic selenium(Selenium melt) is stronger than that by inorganic selenium (Na2SeO3 ) and better or nearly equal to ZnSO4 which is accepted and used by popular as a good one of the synthesis which can induce MT; Using SELDI-TOF-MS we found the protein expression difference of mice serum and liver among control group, injury group and pre-treat group, three biomarker had be found in serum on WCX proteinchip：5062.5Da , 5566.5Da, 6358.5Da；In liver tissue there are four biomarker ：5449.6Da, 7131.5Da, 9903.2Da and 10767.3Da found on WCX proteinchip。The experiments demonstrated Selenium, special organic selenium(Selenium melt) be a strong and novel MT in the future, and can protect the liver injury by selenium.
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Received: 04 April 2006
Published: 25 June 2006
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