中国生物工程杂志

Poly(hydroxybutyrate-co-hydroxyhexanoate) (PHBHHx), a member of the polyhydroxyalkanoate family of biopolyesters, has superior mechanical properties and biocompatibilities that enable it to meet diverse biomedical requirements. One of the degradation product of PHBHHx is oligo-hydroxybutyrate (OPHB), whose derivatives and complexes are occurrent in organisms in a wide range. OPHB ramification is yielded by alcoholysis of Poly(hydroxybutyrate) (PHB). The effects of OPHB and its ramification treatment on human microvascular endothelial cells (HMECs) were investigated by MTT assay. OPHB ramification yielded showed cell toxicity, while OPHB promoted cell viability slightly, and more remarkable in semistarvation batch culture. This effect may underlie the good biocompatibility observed for PHBHHx.