中国生物工程杂志

3-Dehydroshikimic acid (DHS) is an intermediate in the pathway of aromatic amino acid biosynthesis and is shown to serve as a suitable starting compound for the renewable production of a variety of industrial chemicals . The biocatalysis using renewable material as feedstocks has less environmental pollution compared with traditional chemical synthesis. In addition, DHS can be used as a potent antioxidant. Chemical synthesis and fermentive method is the major industrial way to produce DHS, and microbial rational modification based on the development of metabolic engineering made the fermentive method more widely used. In this paper, metabolic engineering in improving DHS-producing microorganisms is reviewed ,involving the regulation of genes and enzymes in biosynthesis pathway of DHS，reconstruction on central metabolism and modification in DHS biosynthesis branch，moreover ,the prospect of DHS production is also mentioned．