中国生物工程杂志

Escherichia coli was used to produce acidic fibroblast growth factor(aFGF) of high purity, and its effect on proliferation of 3T3 and improvement of bald rats were studied. The result shows that in vitro aFGF at the level from 1.95 ng/ml to 1000ng/ml can promote the proliferation of balb/c 3T3, which has significant difference when compared with the control group(P<0.05，P<0.01). In vivo aFGF at the level of 2μg/ml and 4μg/ml can improve the bald hair of the rats, which also has significant difference when compared with the control group (P<0.05). Pathology result proves that aFGF can improve the hair numbers of the bald rats, as well as the hyperaemia situation of the veins. We conclude that aFGF has good future in clinical research.