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| Study on the Inhibition Effect of DKP on the Biofilms Formed by Three Pathogens |
| WANG Jian-hua1,2, QUAN Chun-shan3, ZHAO Peng-chao1,2, FAN Sheng-di3 |
1. Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,China;
2. Graduate School of Chinese Academy of Sciences,Beijing 100049,China;
3. Department of Life Science,Dalian Nationalities University,Dalian 116600,China |
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Abstract The biofilms make it more difficult to treat the diseases caused by pathogens with antibiotics. A kind of diketopiperazine(DKP)——cyclo(Pro-Phe)were found can inhibit the biofilms formation of Staphylococcus aureus,Pseudomonas aeruginosa and Candida albicans. The results of crystal violet staining,CFU(colony forming unit)analysis,and the structure analysis by optical microscope and atomic force microscope indicated that the biofilms of S. aureus and P. aeruginosa were almost disappeared with 10 mg/ml DKP,and the biofilms of C. albicans was significantly inhibited by 12 mg/ml DKP. This brings hope to the research work of novel biofilm inhibitors and cure of the biofilms-associated infections.
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Received: 20 April 2011
Published: 25 August 2011
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