Abstract In plant genetic engineering, selectable marker is needed to distinguish transformant. As the commercialization of transgenic plants, people are more and more paying close attention to their safety, among which refers to the safety of selectable marker. In order to increase the safety of transgenic plants, Biologists began to search for biosafe selectable marker. Here we overview current research progress of taking key enzyme in metabolic pathways，which include glycometabolism, amino acid metabolism, hormone metabolism ,nucleotide metabolism and protein metabolism et cetera, as selectable marker in transgenic plants.
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