中国生物工程杂志

［1］ Burg R W, Miller B M, Baker E E, et al. Avermectins, new family of potent anthelmintic agents: producing organism and fermentation. Antimicrob Agents Chemother, 1979, 15(3): 361367. 
［2］ Ikeda H, Omura S. Control of avermectin biosynthesis in Streptomyces avermitilis for the selective production of a useful component. J Antibiot, 1995, 48(7): 549562. 
［3］ Ikeda H, Nonomiya T, Usami M, et al. Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis. Proc Natl Acad Sci USA, 1999, 96(17): 95099514. 
［4］ Ikeda H, Ishikawa J, Hanamoto A, et al. Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nat Biotechnol, 2003, 21(5): 526531. 
［5］ Denoya C D, Fedechko R W, Hafner E W, et al. A second branchedchain alphaketo acid dehydrogenase gene cluster(bkdFGH) from Streptomyces avermitilis: its relationship to avermectin biosynthesis and the construction of a bkdF mutant suitable for the production of novel antiparasitic avermectins. J Bacteriol, 1995, 177(12): 35043511. 
［6］ 姜薇, 汪洋, 张晓琳, 等. 阿维菌素衍生物CHCB1的突变生物合成. 中国生物工程杂志, 2009, 29(8): 6874. Jiang W, Wang Y, Zhang X L, et al.China biotechnology, 2009, 29(8): 6874. 
［7］ Cropp T A, Wilson D J, Reynolds K A. Identification of a cyclohexylcarbonyl CoA biosynthetic gene cluster and application in the production of doramectin. Nat Biotechnol, 2000, 18(9): 980983. 
［8］ 房春林, 杨光有, 古小彬, 等. 多拉菌素的研究进展. 中国畜牧兽医, 2006, 33(5): 5557. Fang C L, Yang Y G, Gu X B, et al.China Anim Hus Vet Med, 2006, 33(5): 5557. 
［9］ Ikeda H, Wang L R, Ohta T, et al. Cloning of the gene encoding avermectin B 5Omethyltransferase in avermectinproducing Streptomyces avermitilis. Gene, 1998, 206(2): 175180. 
［10］ Bierman M, Logan R, O′Brien K, et al. Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp. Gene, 1992, 116(1): 4349. 
［11］ Hanahan D. Studies on transformation of Escherichia coli with plasmids. J Mol Biol,1983, 166(4): 557580. 
［12］ Sambrook J, Russell D. Molecular Cloning: A Laboratory Manual. 3rd ed. New York: Cold Spring Harbor Laboratory Press, 2001. 
［13］ MacNeil D J, Klapko L M. Transformation of Streptomyces avermitilis by plasmid DNA.J Ind Microbiol, 1987, 2(4): 209218. 
［14］ Ikeda H, Kotaki H, Tanaka H, et al. Involvement of glucose catabolism in avermectin production by Streptomyces avermitilis. Antimicrob Agents Chemother, 1988, 32(2): 282284. 
［15］ Hopwood D A, Bibb M J, Chater K F, et al. Genetic manipulation of Streptomyces: A Laboratory Manual. Norwich: John Innes Foundation, 1985. 
［16］ 姜薇. 多拉菌素的突变生物合成及发酵条件优化. 哈尔滨: 东北农业大学, 生命科学学院，2009. Jiang W. The mutational biosynthesis of doramectin and studies on the fermentation condition. Harbin: Northeast Agricultural University, College of life Sciences,2009. 
［17］ 陈芝, 文莹, 宋渊, 等. 阿维链霉菌中aveD基因缺失对阿维菌素合成的影响. 微生物学报, 2002, 42(5): 534538. Chen Z, Wen Y, Song Y, et al.Acta Microbiol Sin, 2002, 42(5): 534538. 
［18］ StutzmanEngwall K, Conlon S, Fedechko R, et al. Engineering the aveC gene to enhance the ratio of doramectin to its CHCB2 analogue produced in Streptomyces avermitilis. Biotechnol Bioeng, 2003, 82(3): 359369.