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Genetic Features and Modification of Clostridium acetobutylicum and Clostridium beijerinckii for Acetone Butanol and Ethanol Fermentation |
YANG Ming1,LIU Li-qiang1,NIU Kun1,JIA Juan-juan1,LI Yin2,ZHANG Yan-ping2,WANG Zheng-pin1 |
1.North China Pharmaceutical Biofuel Research Institute, Shijiazhuang 050015, China
2.Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China |
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Abstract Clostridium acetobutylicum and C.beijerinckii are extensively studied strains for producing ABE (Acetone, Butanol and Ethanol). Both acetone and butanol from ABE fermentation are widely used as important chemicals and raw materials. Butanol has been also recognized as a kind of potential biofuel or fuel additive with better performances than ethanol in the car engine tests. Genetic engineering has been broadly applied in the modification of these strains based on current industrial requirements and development of new biological technologies.The genetic features of C. acetobutylicum and C. beijerinckii, and progressive achievements on genetic manipulations of these strains were reviewed.
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Received: 25 May 2009
Published: 29 October 2009
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